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Human Reproduction Update, Vol.1, No.4 pp.385-396, 1995
© © Oxford University Press
research-article |
Cytokines in implantation
Departments of Reproductive Physiology and Obstetrics & Gynaecology, St Bartholomew's Hospital Medical College and The London Hospital Medical College London, UK
To whom correspondence should be addressed at: 1Address for correspondence: Department of Reproductive Physiology, St Bartholomew's Hospital. West Smithfield, London ECIA 7BE, UK. Fax: 0171-600 1439
The process of implantation in the human involves ‘invasion’ of the maternal endometrium by the tro-phoblast surrounding the developing blastocyst, in response to which there is a cellular reaction in the endometrium. The overall situation has some features analogous to invasion by a tumour and some which are more characteristic of an inflammatory response. In addition, and also in common with cancer and inflammation, there is a release of biologically active molecules, including cytokines, at and around the implantation site. It is believed that these cytokines may play an important role in the successful establishment of the pregnancy; the evidence for this belief is examined in this review.
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