Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (33)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Chappel, S.C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chappel, S.C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction Update, Vol.1, No.5 pp.479-487, 1995
© © Oxford University Press

research-article

Heterogeneity of follicle stimulating hormone: control and physiological function

S.C. Chappel1

Ares-Serono, Inc. Randolph, Massachusetts 02368, USA

The existence of a heterogeneous population of follicle stimulating hormone (FSH) was described many years ago. Other pituitary glycoproteins, such as thyroid stimulating hormone (TSH) and luteinizing hormone (LH) as well as placental human chorionic gonadotrophin (HCG) also exhibit heterogeneity. Because FSH plays a significant role in a variety of ovarian activities such as follicular maturation, selection of the dominant follicle and ovulation, the possible role of sub-populations of FSH with distinct physicochemical characteristics is of great interest. After a great deal of investigation, the physiological significance of this biochemical phenomenon has yet to be fully understood. Investigators have employed immunoassays, in-vitro bioassays and radioreceptor assays to study the biological activity of the individual isoforms ofFSH. As more informations has accumulated, it has become clear that some ofthe initial assumptions used to interpret data may be incorrect. This review is Provided to Update the reader with availableinformation on the topic as it relates to FSH and to pointout issues that require re-evaluation in this area.

Key words: bioactivity / folliele stimulating hormone / heterogeneity / immunoactivity / isohormones


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
L. M. Mitchell, C. R. Kennedy, and G. M. Hartshorne
Effects of varying gonadotrophin dose and timing on antrum formation and ovulation efficiency of mouse follicles in vitro
Hum. Reprod., May 1, 2002; 17(5): 1181 - 1188.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Ulloa-Aguirre, C. Timossi, and J.P. Mendez
Is there any physiological role for gonadotrophin oligosaccharide heterogeneity in humans?: I. Gondatrophins are synthesized and released in multiple molecular forms. A matter of fact
Hum. Reprod., April 1, 2001; 16(4): 599 - 604.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
C.Y. Andersen, L. Leonardsen, A. Ulloa-Aguirre, J. Barrios-De-Tomasi, K.S. Kristensen, and A.G. Byskov
Effect of different FSH isoforms on cyclic-AMP production by mouse cumulus-oocyte-complexes: a time course study
Mol. Hum. Reprod., February 1, 2001; 7(2): 129 - 135.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Olivares, M. Cardenas, C. Timossi, T. Zarinan, V. Diaz-Sanchez, and A. Ulloa-Aguirre
Reactivity of different LH and FSH standards and preparations in the World Health Organization matched reagents for enzyme-linked immunoassays of gonadotrophins
Hum. Reprod., November 1, 2000; 15(11): 2285 - 2291.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G. Horsman, J.A. Talbot, J.D. McLoughlin, A. Lambert, and W.R. Robertson
A biological, immunological and physico-chemical comparison of the current clinical batches of the recombinant FSH preparations Gonal-F and Puregon
Hum. Reprod., September 1, 2000; 15(9): 1898 - 1902.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. P. Rose, R. E. Gaines Das, and A. H. Balen
Definition and Measurement of Follicle Stimulating Hormone
Endocr. Rev., February 1, 2000; 21(1): 5 - 22.
[Abstract] [Full Text]

Home page
 Hum ReprodHome page
J. Harlin, G. Csemiczky, H. Wramsby, and G. Fried
Recombinant follicle stimulating hormone in in-vitro fertilization treatment--clinical experience with follitropin alpha and follitropin beta
Hum. Reprod., February 1, 2000; 15(2): 239 - 244.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Daya and J. Gunby
Recombinant versus urinary follicle stimulating hormone for ovarian stimulation in assisted reproduction
Hum. Reprod., September 1, 1999; 14(9): 2207 - 2215.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
C. Y. Andersen, L. Leonardsen, A. Ulloa-Aguirre, J. Barrios-De-Tomasi, L. Moore, and A.G. Byskov
FSH-induced resumption of meiosis in mouse oocytes: effect of different isoforms
Mol. Hum. Reprod., August 1, 1999; 5(8): 726 - 731.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
B. C. J. M. Fauser and A. M. van Heusden
Manipulation of Human Ovarian Function: Physiological Concepts and Clinical Consequences
Endocr. Rev., February 1, 1997; 18(1): 71 - 106.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.