Human Reproduction Update, Vol.10, No.1 pp.3-18, 2004
© European Society of Human Reproduction and Embryology 2004; all rights reserved
Potential significance of genomic imprinting defects for reproduction and assisted reproductive technology
1 McGill University–Montreal Children’s Hospital Research Institute and Departments of Paediatrics, Human Genetics, and Pharmacology & Therapeutics, McGill University, Montreal, Quebec, H3H 1P3, Canada and 2 University of Pittsburgh, Department of Molecular Genetics and Biochemistry, Pittsburgh, PA 15213, USA 3 To whom correspondence should be addressed at: McGill University-Montreal Children’s Hospital Research Institute, 2300 Tupper Street, Montreal, Quebec. Canada H3H 1P3. e-mail: jacquetta.trasler{at}mcgill.ca
Recent studies suggest a possible link between human assisted reproductive technology and genomic imprinting disorders. Assisted reproductive technology includes the isolation, handling and culture of gametes and early embryos at times when imprinted genes are likely to be particularly vulnerable to external influences. Evidence of sex-specific differences in imprint acquisition suggests that male and female germ cells may be susceptible to perturbations in imprinted genes at specific prenatal and postnatal stages. Imprints acquired first during gametogenesis must be maintained during preimplantation development when reprogramming of the overall genome occurs. In this review, we will discuss both new developments in our understanding of genomic imprinting including the mechanisms and timing of imprint erasure, acquisition and maintenance during germ cell development and early embryogenesis as well as the implications of this research for future epigenetic studies in reproduction and assisted reproductive technology.
Key words: Angelman syndrome/assisted reproductive technology/Beckwith–Wiedemann syndrome/genomic imprinting/reproduction
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. M. Zama and M. Uzumcu Fetal and Neonatal Exposure to the Endocrine Disruptor Methoxychlor Causes Epigenetic Alterations in Adult Ovarian Genes Endocrinology, October 1, 2009; 150(10): 4681 - 4691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I R Makhoul, A Tamir, D Bader, A Rotschild, Z Weintraub, S Yurman, D Reich, Y Bental, J Jammalieh, T Smolkin, et al. In vitro fertilisation and use of ovulation enhancers may both influence childhood height in very low birthweight infants Arch. Dis. Child. Fetal Neonatal Ed., September 1, 2009; 94(5): F355 - F359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.V. Gomes, J. Huber, R.A. Ferriani, A.M. Amaral Neto, and E.S. Ramos Abnormal methylation at the KvDMR1 imprinting control region in clinically normal children conceived by assisted reproductive technologies Mol. Hum. Reprod., August 1, 2009; 15(8): 471 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Fortier, F. L. Lopes, N. Darricarrere, J. Martel, and J. M. Trasler Superovulation alters the expression of imprinted genes in the midgestation mouse placenta Hum. Mol. Genet., June 1, 2008; 17(11): 1653 - 1665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Toppings, C. Castro, P. H. Mills, B. Reinhart, G. Schatten, E. T. Ahrens, J. R. Chaillet, and J. M. Trasler Profound phenotypic variation among mice deficient in the maintenance of genomic imprints Hum. Reprod., April 1, 2008; 23(4): 807 - 818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A D. Smith, Y.-I. Kim, and H. Refsum Is folic acid good for everyone? Am. J. Clinical Nutrition, March 1, 2008; 87(3): 517 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B Mahsoudi, A Li, and C O'Neill Assessment of the Long-Term and Transgenerational Consequences of Perturbing Preimplantation Embryo Development in Mice Biol Reprod, November 1, 2007; 77(5): 889 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Biermann and K. Steger Epigenetics in Male Germ Cells J Androl, July 1, 2007; 28(4): 466 - 480. [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Rosenwaks and K. Bendikson Further evidence of the safety of assisted reproductive technologies PNAS, April 3, 2007; 104(14): 5709 - 5710. [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Price, S. K. Murphy, and E. V. Younglai Perspectives: The Possible Influence of Assisted Reproductive Technologies on Transgenerational Reproductive Effects of Environmental Endocrine Disruptors Toxicol. Sci., April 1, 2007; 96(2): 218 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Allegrucci and L.E. Young Differences between human embryonic stem cell lines Hum. Reprod. Update, March 1, 2007; 13(2): 103 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sato, E. Otsu, H. Negishi, T. Utsunomiya, and T. Arima Aberrant DNA methylation of imprinted loci in superovulated oocytes Hum. Reprod., January 1, 2007; 22(1): 26 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-S. Chang, M. D. Anway, S. S. Rekow, and M. K. Skinner Transgenerational Epigenetic Imprinting of the Male Germline by Endocrine Disruptor Exposure during Gonadal Sex Determination Endocrinology, December 1, 2006; 147(12): 5524 - 5541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lucifero, J. Suzuki, V. Bordignon, J. Martel, C. Vigneault, J. Therrien, F. Filion, L. C. Smith, and J. M. Trasler Bovine SNRPN Methylation Imprint in Oocytes and Day 17 In Vitro-Produced and Somatic Cell Nuclear Transfer Embryos Biol Reprod, October 1, 2006; 75(4): 531 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ptak, K. Matsukawa, C. Palmieri, L. D. Salda, P. A. Scapolo, and P. Loi Developmental and functional evidence of nuclear immaturity in prepubertal oocytes Hum. Reprod., September 1, 2006; 21(9): 2228 - 2237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Horsthemke and M. Ludwig Assisted reproduction: the epigenetic perspective Hum. Reprod. Update, September 1, 2005; 11(5): 473 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Seli and D. Sakkas Spermatozoal nuclear determinants of reproductive outcome: implications for ART Hum. Reprod. Update, July 1, 2005; 11(4): 337 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
ESHRE Capri Workshop Group Fertility and ageing Hum. Reprod. Update, May 1, 2005; 11(3): 261 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Boklage The epigenetic environment: secondary sex ratio depends on differential survival in embryogenesis Hum. Reprod., March 1, 2005; 20(3): 583 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Fulka, M. Mrazek, O. Tepla, and J. Fulka Jr DNA methylation pattern in human zygotes and developing embryos Reproduction, December 1, 2004; 128(6): 703 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. P. Fleming, W. Y. Kwong, R. Porter, E. Ursell, I. Fesenko, A. Wilkins, D. J. Miller, A. J. Watkins, and J. J. Eckert The Embryo and Its Future Biol Reprod, October 1, 2004; 71(4): 1046 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lucifero, M. R.W. Mann, M. S. Bartolomei, and J. M. Trasler Gene-specific timing and epigenetic memory in oocyte imprinting Hum. Mol. Genet., April 15, 2004; 13(8): 839 - 849. [Abstract] [Full Text] [PDF]
|
|