Human Reproduction Update Advance Access originally published online on September 23, 2004
Human Reproduction Update 2004 10(6):503-513; doi:10.1093/humupd/dmh043
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Ectopic pregnancies after infertility treatment: modern diagnosis and therapeutic strategy
1 Service de Gynécologie Obstetrique du Professeur René Frydman, Hôpital Antoine Béclère
2 To whom correspondence should be addressed at: Service de Gynécologie Obstétrique, Hôpital Antoine Beclere, 157 rue de la Porte de Trivaux, 92141 Clamart Cedex. Email: herve.fernandez{at}abc.ap-hop-paris.fr
Ectopic pregnancy (EP) is a major event in a woman's reproductive life. It complicates infertility treatment and must be recognized early to simplify the treatment strategy, which must always be directed towards optimizing subsequent fertility. Epidemiological findings indicate that tubal history and smoking are the principal risk factors of those EP that are considered reproductive (rather than contraceptive) failures. Adding together the attributable risks for EP allows the construction of a risk scale to determine its probability for any given patient. This risk calculation makes it easier to establish a diagnostic strategy that uses abdominal and transvaginal ultrasound and hCG assays. Progesterone assays are useful only for determining the activity of the pregnancy but do not help to identify its site. Conservative treatment is to be preferred unless the EP occurs on a known hydrosalpinx. All the treatment trials and the Cochrane database meta-analysis show that medical treatment with methotrexate, preferably multidose, is equivalent in efficacy to conservative treatment with laparoscopy in the populations studied. Heterotopic pregnancies, which occur most often after assisted reproduction technology (1–3%), should preferably be treated by salpingectomy except in interstitial sites. There is no consensus that IVF is indicated after EP. The patient's age is probably the determining factor: fertility treatment should not be delayed to an age where the results would be altered, especially with the risk of a recurrent EP.
Key words: assisted reproduction technology / ectopic pregnancy / fertility / laparoscopy / medical treatment
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