Human Reproduction Update Advance Access originally published online on December 15, 2004
Human Reproduction Update 2005 11(1):43-57; doi:10.1093/humupd/dmh055
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Environmental and occupational factors affecting fertility and IVF success
Department of Obstetrics & Gynaecology, Reproductive Biology Division, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada
1 To whom correspondence should be addressed at: Department of Obstetrics & Gynaecology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5. Email: younglai{at}mcmaster.ca
Reproductive function has been shown to be sensitive to changes in the physical, psychosocial and chemical environments. Although reproductive effects of occupational exposure to hazardous chemicals have been well documented in the literature, the potential effects of chemical contaminants at levels representative of contemporary exposures in the general population are much less certain. Evidence for adverse effects of exposure to environmental contaminants is more conclusive among the lower animals than for humans where considerable controversy remains. In addition to potential reproductive hazards of exposure to environmental contaminants, there is also evidence for adverse reproductive effects of the physical and psychosocial environments. In this review we focus on the difficulties involved in linking exposure to putative hazardous substances in environmental and occupational settings to adverse reproductive outcomes, especially success of IVF procedures. We highlight the plausibility of adverse events through animal and cell studies and the application of these results to the interpretation of human data. We consider both the male and female partners since it is essentially their combined contributions of gametes which may be affected by chemicals, which lead to successful outcomes.
Key words: environmental contaminants / IVF / polychlorinated biphenyls / pesticides
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. M. Zama and M. Uzumcu Fetal and Neonatal Exposure to the Endocrine Disruptor Methoxychlor Causes Epigenetic Alterations in Adult Ovarian Genes Endocrinology, October 1, 2009; 150(10): 4681 - 4691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Xia, P. Zhu, Y. Han, C. Lu, S. Wang, A. Gu, G. Fu, R. Zhao, L. Song, and X. Wang Urinary metabolites of polycyclic aromatic hydrocarbons in relation to idiopathic male infertility Hum. Reprod., May 1, 2009; 24(5): 1067 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.F. Homan, M. Davies, and R. Norman The impact of lifestyle factors on reproductive performance in the general population and those undergoing infertility treatment: a review Hum. Reprod. Update, May 1, 2007; 13(3): 209 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Breton and D. Brown New insights into the regulation of V-ATPase-dependent proton secretion Am J Physiol Renal Physiol, January 1, 2007; 292(1): F1 - F10. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wu, W. G Foster, and E. V Younglai Rapid effects of pesticides on human granulosa-lutein cells Reproduction, February 1, 2006; 131(2): 299 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Pastor-Soler, C. Pietrement, and S. Breton Role of Acid/Base Transporters in the Male Reproductive Tract and Potential Consequences of Their Malfunction Physiology, December 1, 2005; 20(6): 417 - 428. [Abstract] [Full Text] [PDF]
|
|