Skip Navigation


Human Reproduction Update Advance Access originally published online on January 27, 2005
Human Reproduction Update 2005 11(2):137-142; doi:10.1093/humupd/dmh060
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
11/2/137    most recent
dmh060v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (4)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Devriendt, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Devriendt, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction Update Vol. 11 No. 2 © European Society of Human Reproduction and Embryology 2005; all rights reserved

Hydatidiform mole and triploidy: the role of genomic imprinting in placental development

Koen Devriendt

Center for Human Genetics, Herestraat 49, B-3000 Leuven, Belgium. Email: koenraad.devriendt{at}uz.kuleuven.ac.be

Genomic imprinting, the differential expression of paternal and maternal alleles, is involved in the regulation of embryonic and fetal growth and development. In this review, we focus on the genetics of a disorder caused by a global defect in genomic imprinting, the hydatidiform mole. The ratio between the maternal and paternal genomes is critical in determining the development of both the embryonic and extraembryonic tissues, with an excess of paternally derived chromosomes leading to a complete (no maternal genome) or partial (lower amount of maternal chromosomes) mole. The recent identification and molecular studies in biparental complete moles may yield more insight into the regulation of imprinting during gametogenesis.

Key words: genomic imprinting / hydatidiform mole / methylation / pregnancy / triploidy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
P. Arnaud, K. Hata, M. Kaneda, E. Li, H. Sasaki, R. Feil, and G. Kelsey
Stochastic imprinting in the progeny of Dnmt3L-/- females
Hum. Mol. Genet., February 15, 2006; 15(4): 589 - 598.
[Abstract] [Full Text] [PDF]

Home page
 CMAJHome page
D. Rodenhiser and M. Mann
Epigenetics and human disease: translating basic biology into clinical applications
Can. Med. Assoc. J., January 31, 2006; 174(3): 341 - 348.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.