Human Reproduction Update Advance Access originally published online on February 10, 2005
Human Reproduction Update 2005 11(2):162-178; doi:10.1093/humupd/dmi001
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Apoptosis in the ovary: molecular mechanisms
Department of Pathology, Assiut University Hospitals, Assiut, Egypt
Email:mrh17{at}swissinfo.org
Cell death was first described in rabbit ovaries (Graaffian follicles), the phenomenon being called ‘chromatolysis’ rather than apoptosis. In humans, the ovarian endowment of primordial follicles is established during fetal life. Apoptotic cell death depletes this endowment by at least two-thirds before birth, executed with the help of several players and pathways conserved from worms to humans. To date, apoptosis has been reported to be involved in oogenesis, folliculogenesis, oocyte loss/selection and atresia. Several pro-survival and pro-apoptotic molecules are involved in ovarian apoptosis with the delicate balance between them being the determinant for the final destiny of the follicular cells. This review critically analyses the current knowledge about the biological roles of these molecules and their relevance to the dynamics of follicle development. It also presents the existing literature and assesses the gaps in our knowledge.
Key words: apoptosis / death / ovary
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G.M. Hartshorne, S. Lyrakou, H. Hamoda, E. Oloto, and F. Ghafari Oogenesis and cell death in human prenatal ovaries: what are the criteria for oocyte selection? Mol. Hum. Reprod., December 1, 2009; 15(12): 805 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Wallace and W. Fan The pathophysiology of mitochondrial disease as modeled in the mouse Genes & Dev., August 1, 2009; 23(15): 1714 - 1736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Tingen, S. K. Bristol-Gould, S. E. Kiesewetter, J. T. Wellington, L. Shea, and T. K. Woodruff Prepubertal Primordial Follicle Loss in Mice Is Not Due to Classical Apoptotic Pathways Biol Reprod, July 1, 2009; 81(1): 16 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Cetin, C. Berti, and S. Calabrese Role of micronutrients in the periconceptional period Hum. Reprod. Update, June 30, 2009; (2009) dmp025v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Ghafari, S. Pelengaris, E. Walters, and G.M. Hartshorne Influence of p53 and genetic background on prenatal oogenesis and oocyte attrition in mice Hum. Reprod., June 1, 2009; 24(6): 1460 - 1472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mazoochi, M. Salehnia, S. Pourbeiranvand, M. Forouzandeh, S. J. Mowla, and E. Hajizadeh Analysis of apoptosis and expression of genes related to apoptosis in cultures of follicles derived from vitrified and non-vitrified ovaries Mol. Hum. Reprod., March 1, 2009; 15(3): 155 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Orimoto, K. Dumaresq-Doiron, J.-Y. Jiang, N. Tanphaichitr, B. K. Tsang, and E. Carmona Mammalian Hyaluronidase Induces Ovarian Granulosa Cell Apoptosis and Is Involved in Follicular Atresia Endocrinology, November 1, 2008; 149(11): 5835 - 5847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I.-S. Hong, A. P. Cheung, and P. C. K. Leung Gonadotropin-Releasing Hormones I and II Induce Apoptosis in Human Granulosa Cells J. Clin. Endocrinol. Metab., August 1, 2008; 93(8): 3179 - 3185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Anupriwan, M. Schenk, K. Kongmanas, R. Vanichviriyakit, D. Costa Santos, A. Yaghoubian, F. Liu, A. Wu, T. Berger, K. F. Faull, et al. Presence of Arylsulfatase A and Sulfogalactosylglycerolipid in Mouse Ovaries: Localization to the Corpus Luteum Endocrinology, August 1, 2008; 149(8): 3942 - 3951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Fan, K. G. Waymire, N. Narula, P. Li, C. Rocher, P. E. Coskun, M. A. Vannan, J. Narula, G. R. MacGregor, and D. C. Wallace A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations Science, February 15, 2008; 319(5865): 958 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Zachow and M. Uzumcu The hepatocyte growth factor system as a regulator of female and male gonadal function J. Endocrinol., December 1, 2007; 195(3): 359 - 371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J Agulleiro, M. Andre, S. Morais, J. Cerda, and P. J Babin High Transcript Level of Fatty Acid-Binding Protein 11 but Not of Very Low-Density Lipoprotein Receptor Is Correlated to Ovarian Follicle Atresia in a Teleost Fish (Solea senegalensis) Biol Reprod, September 1, 2007; 77(3): 504 - 516. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wang and B. K Tsang Nodal signalling and apoptosis Reproduction, May 1, 2007; 133(5): 847 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Forges, P. Monnier-Barbarino, J.M. Alberto, R.M. Gueant-Rodriguez, J.L. Daval, and J.L. Gueant Impact of folate and homocysteine metabolism on human reproductive health Hum. Reprod. Update, May 1, 2007; 13(3): 225 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Bedaiwy, M. R. Hussein, C. Biscotti, and T. Falcone Cryopreservation of intact human ovary with its vascular pedicle Hum. Reprod., December 1, 2006; 21(12): 3258 - 3269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Orisaka, S. Orisaka, J.-Y. Jiang, J. Craig, Y. Wang, F. Kotsuji, and B. K. Tsang Growth Differentiation Factor 9 Is Antiapoptotic during Follicular Development from Preantral to Early Antral Stage Mol. Endocrinol., October 1, 2006; 20(10): 2456 - 2468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Forges, P. Monnier-Barbarino, B. Leheup, and P. Jouvet Pathophysiology of impaired ovarian function in galactosaemia Hum. Reprod. Update, September 1, 2006; 12(5): 573 - 584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Uzumcu, Z. Pan, Y. Chu, P. E Kuhn, and R. Zachow Immunolocalization of the hepatocyte growth factor (HGF) system in the rat ovary and the anti-apoptotic effect of HGF in rat ovarian granulosa cells in vitro. Reproduction, August 1, 2006; 132(2): 291 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Hurst, J. M. Mora, and M. A. Fenwick Caspase-3, TUNEL and ultrastructural studies of small follicles in adult human ovarian biopsies Hum. Reprod., August 1, 2006; 21(8): 1974 - 1980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Fleming, N. Deshpande, I. Traynor, and R.W.S. Yates Dynamics of FSH-induced follicular growth in subfertile women: relationship with age, insulin resistance, oocyte yield and anti-Mullerian hormone Hum. Reprod., June 1, 2006; 21(6): 1436 - 1441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Skinner Regulation of primordial follicle assembly and development Hum. Reprod. Update, September 1, 2005; 11(5): 461 - 471. [Abstract] [Full Text] [PDF]
|
|