Human Reproduction Update Advance Access originally published online on August 25, 2005
Human Reproduction Update 2006 12(1):3-12; doi:10.1093/humupd/dmi030
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Are endogenous LH levels during ovarian stimulation for IVF using GnRH analogues associated with the probability of ongoing pregnancy? A systematic review
1 Department of Obstetrics and Gynaecology, Unit for Human Reproduction, Aristotle University of Thessaloniki, Thessaloniki, Greece, 2 McMaster University, Hamilton, Ontario, 3 Dalhousie University, Halifax, Nova Scotia, Canada and 4 Centre for Reproductive Medicine, Dutch-Speaking Brussels Free University, Brussels, Belgium
5 To whom correspondence should be addressed at: Unit for Human Reproduction, Papageorgiou General Hospital, Nea Efkarpia Peripheral Road, Thessaloniki 54603, Greece. E-mail: stratis.kolibianakis{at}otenet.gr
Submitted on June 6, 2005; revised on July 5, 2005; accepted on July 18, 2005.
The aim of this systematic review was to evaluate, among women with normal ovulation or World Health Organization (WHO) II oligoanovulation who undergo ovarian stimulation for IVF using GnRH analogues, whether endogenous LH levels predict the likelihood of ongoing pregnancy beyond 12 weeks. A literature search identified six studies that answered the research question, among which two were prospective studies (one in GnRH agonist and one in GnRH antagonist cycles). None of the retrospective studies suggest that low endogenous LH levels are associated with a significantly decreased probability of ongoing pregnancy beyond 12 weeks in such patients. In the two prospective studies high endogenous LH levels during down-regulation were associated with a decreased probability of ongoing pregnancy beyond 12 weeks. Until further prospective studies modify the existing evidence summarized here, an adverse effect of low endogenous LH levels on the probability of ongoing pregnancy beyond 12 weeks is not a sensible rationale for LH supplementation during ovarian stimulation for IVF using GnRH analogues.
Key words: GnRH agonists / GnRH antagonists / luteinizing hormone / ongoing pregnancy rate
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. A.B. Klemmt, F. Liu, J. G. Carver, C. Jones, D. Brosi, J. Adamson, H. J. Mardon, and E. McVeigh Effects of gonadotrophin releasing hormone analogues on human endometrial stromal cells and embryo invasion in vitro Hum. Reprod., June 22, 2009; (2009) dep181v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.F.G. Verberg, M.J.C. Eijkemans, N.S. Macklon, E.M.E.W. Heijnen, E.B. Baart, F.P. Hohmann, B.C.J.M. Fauser, and F.J. Broekmans The clinical significance of the retrieval of a low number of oocytes following mild ovarian stimulation for IVF: a meta-analysis Hum. Reprod. Update, January 1, 2009; 15(1): 5 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kol and R. Homburg Change, change, change: hormonal actions depend on changes in blood levels Hum. Reprod., May 1, 2008; 23(5): 1004 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. NyboeAndersen, P. Humaidan, G. Fried, J. Hausken, L. Antila, S. Bangsboll, P.E. Rasmussen, S. Lindenberg, H. E. Bredkjaer, H. Meinertz, et al. Recombinant LH supplementation to recombinant FSH during the final days of controlled ovarian stimulation for in vitro fertilization. A multicentre, prospective, randomized, controlled trial Hum. Reprod., February 1, 2008; 23(2): 427 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Coomarasamy, M. Afnan, D. Cheema, F. van der Veen, P. M.M. Bossuyt, and M. van Wely Urinary hMG versus recombinant FSH for controlled ovarian hyperstimulation following an agonist long down-regulation protocol in IVF or ICSI treatment: a systematic review and meta-analysis Hum. Reprod., February 1, 2008; 23(2): 310 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.C.J.M. Fauser, K. Diedrich, P. Devroey, and on behalf of the Evian Annual Reproduction (EVAR) Predictors of ovarian response: progress towards individualized treatment in ovulation induction and ovarian stimulation Hum. Reprod. Update, January 1, 2008; 14(1): 1 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Griesinger, M. Weig, A. Schroer, K. Diedrich, and E.M. Kolibianakis Mid-cycle serum levels of endogenous LH are not associated with the likelihood of pregnancy in artificial frozen-thawed embryo transfer cycles without pituitary suppression Hum. Reprod., October 1, 2007; 22(10): 2589 - 2593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.M. Kolibianakis, L. Kalogeropoulou, G. Griesinger, E.G. Papanikolaou, J. Papadimas, J. Bontis, and B.C. Tarlatzis Among patients treated with FSH and GnRH analogues for in vitro fertilization, is the addition of recombinant LH associated with the probability of live birth? A systematic review and meta-analysis Hum. Reprod. Update, September 1, 2007; 13(5): 445 - 452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Humaidan Are endogenous LH levels during ovarian stimulation for IVF using GnRH analogues associated with the probability of ongoing pregnancy? A systematic review Hum. Reprod. Update, May 1, 2006; 12(3): 325 - 326. [Full Text] [PDF]
|
|
|
|
|
|
E.M. Kolibianakis, J. Collins, B. Tarlatzis, E. Papanikolaou, and P. Devroey Reply: Are endogenous LH levels during ovarian stimulation for IVF using GnRH analogues associated with the probability of ongoing pregnancy? A systematic review Hum. Reprod. Update, May 1, 2006; 12(3): 326 - 327. [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Macklon, R. L. Stouffer, L. C. Giudice, and B. C. J. M. Fauser The Science behind 25 Years of Ovarian Stimulation for in Vitro Fertilization Endocr. Rev., April 1, 2006; 27(2): 170 - 207. [Abstract] [Full Text] [PDF]
|
|