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Human Reproduction Update Advance Access originally published online on September 2, 2005
Human Reproduction Update 2006 12(1):65-76; doi:10.1093/humupd/dmi033
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. for Permissions, please email: journals.permissions@oupjournals.org

Transcriptional regulation of early oogenesis: in search of masters

Stephanie A. Pangas1 and Aleksandar Rajkovic2,3

1 Department of Pathology and 2 Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA

3 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Baylor College of Medicine, Smith Tower, 6550 Fannin Street, Suite 801A, Houston, TX, USA. E-mail: rajkovic{at}bcm.tmc.edu

Submitted on May 3, 2005; accepted on June 27, 2005.

Transcription factors in the germline play important roles in ovary formation and folliculogenesis, and control both oocyte development and somatic cell function. Factor in the germline (Figla) and newborn ovary homeobox gene (Nobox) represent a growing number of oocyte-specific transcription factors that regulate genes unique to oocytes. Studies on oocyte-specific transcription factors are important in understanding the genetic pathways essential for oogenesis, pluripotency, and embryonic development. Likely, these genes regulate reproductive life span and represent candidate genes for reproductive disorders, such as premature ovarian failure, and infertility. Therefore, oocyte-specific transcription factors, and oocyte-specific genes regulated by such factors, are attractive tissue-specific pharmacological targets to regulate human fertility.

Key words: folliculogenesis / human fertility / mouse knockout models / oocyte-specific transcription factors / oogenesis


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