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Human Reproduction Update Advance Access originally published online on January 30, 2006
Human Reproduction Update 2006 12(3):275-282; doi:10.1093/humupd/dmk001
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Spermatogonial stem cells: questions, models and perspectives

Jens Ehmcke1, Joachim Wistuba2 and Stefan Schlatt1,3

1 Department of Cell Biology and Physiology, Center for Research in Reproductive Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA and 2 Institute of Reproductive Medicine, University of Münster, Domagkstrasse 11, 48149 Münster, Germany

3 To whom correspondence should be addressed: Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, W952 Biomedical Science Tower, 3500 Terrace Street, Pittsburgh, PA 15261, USA. E-mail: schlatt{at}pitt.edu

Submitted on October 10, 2005; resubmitted on November 17, 2005; accepted on December 20, 2005

This review looks into the phylogeny of spermatogonial stem cells and describes their basic biological features. We are focusing on species-specific differences of spermatogonial stem cell physiology. We propose revised models for the clonal expansion of spermatogonia and for the potential existence of true stem cells and progenitors in primates but not in rodents. We create a new model for the species-specific arrangements of spermatogenic stages which may depend on the variable clonal expansion patterns. We also provide a brief overview of germ cell transplantation as a powerful tool for basic research and its potential use in a clinical setting.

Key words: germ cell transplantation / phylogeny / species-specific differences / spermatogonial stem cells


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