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Human Reproduction Update Advance Access originally published online on July 18, 2006
Human Reproduction Update 2006 12(5):519-535; doi:10.1093/humupd/dml032
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Ovarian tissue cryopreservation and transplantation: a review

Jacques Donnez1, Belen Martinez-Madrid, Pascale Jadoul, Anne Van Langendonckt, Dominique Demylle and Marie-Madeleine Dolmans

Department of Gynecology, Université Catholique de Louvain, Brussels, Belgium

1 To whom correspondence should be addressed: Department of Gynecology, Université Catholique de Louvain, Cliniques Universitaires St Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium. E-mail: donnez{at}gyne.ucl.ac.be

The review covers current options for ovarian tissue cryopreservation and transplantation and provides a systematic review of the existing literature from the last 10 years, taking into account all previously published reviews on the subject. The different cryopreservation options available for fertility preservation in cancer patients are embryo cryopreservation, oocyte cryopreservation and ovarian tissue cryopreservation. The choice depends on various parameters: the type and timing of chemotherapy, the type of cancer, the patient’s age and the partner status. The different options and their results are discussed, as well as their putative indications and efficacy. The review concludes that advances in reproductive technology have made fertility preservation techniques a real possibility for patients whose gonadal function is threatened by premature menopause, or by treatments such as radiotherapy, chemotherapy or surgical castration.

Key words: fertility preservation / ovarian tissue cryopreservation / transplantation


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