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Human Reproduction Update Advance Access originally published online on June 21, 2007
Human Reproduction Update 2007 13(5):433-444; doi:10.1093/humupd/dmm017
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Effect of overweight and obesity on assisted reproductive technology—a systematic review

A. Maheshwari1,4, Lawrize Stofberg2 and S. Bhattacharya3

1 Assisted Reproduction Unit, University of Aberdeen, Aberdeen Maternity Hospital, Aberdeen AB25 2ZL, UK 2 Obstetrics and Gynaecology, Aberdeen Royal Infirmary, Aberdeen AB25 2ZL, UK 3 Department of Obstetrics and Gynaecology, Dugald Baird Centre for Research on Women’s Health, School of Medicine University of Aberdeen, Aberdeen AB25 2ZD, UK

4 Correspondence address. Tel: +44-1224-553582; Fax: +44-1224-551072; E-mail: abha.maheshwari{at}abdn.ac.uk

Obesity is known to be associated with sub-optimal reproductive performance but its direct effect on the outcome of assisted reproduction techniques (ART) is less clear. This present study aimed to perform a systematic review of the available evidence to assess the effects of obesity on the outcome of ART. A number of observational studies were identified. Interpretation of the results was compromised by variations in the methods used to define overweight and obese populations and inconsistencies in the choice and definition of outcome measures. Compared with women with a BMI of 25 kg/m2 or less, women with a BMI ≥ 25 kg/m2 have a lower chance of pregnancy following IVF [odds ratio (OR) 0.71, 95% CI: 0.62, 0.81], require higher dose of gonadotrophins (weighed mean differences 210.08, 95% CI: 149.12, 271.05) and have an increased miscarriage rate (OR 1.33, 95% CI: 1.06, 1.68). There is insufficient evidence on the effect of BMI on live birth, cycle cancellation, oocyte recovery and ovarian hyperstimulation syndrome. Further studies with clear entry criteria and uniform reporting of outcomes are needed to investigate the true impact of weight on the outcome of ART.

Key words: obesity / overweight / ART / systematic review / observational studies

Received on December 19, 2006; revised March 19, 2007; accepted on May 10, 2007


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