Skip Navigation


Human Reproduction Update Advance Access originally published online on June 15, 2007
Human Reproduction Update 2007 13(5):453-463; doi:10.1093/humupd/dmm012
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Data
Right arrow All Versions of this Article:
13/5/453    most recent
dmm012v3
dmm012v2
dmm012v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Greiser, C. M.
Right arrow Articles by Dören, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Greiser, C. M.
Right arrow Articles by Dören, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Menopausal hormone therapy and risk of ovarian cancer: systematic review and meta-analysis

Claudia M. Greiser1, Eberhard M. Greiser1,2 and Martina Dören3,4

1 Epi. Consult GmbH, Bremen, Germany 2 Institute for Public Health and Nursing Research, Faculty of Health Sciences, Bremen University, Bremen, Germany 3 Charité—Universitätsmedizin Berlin, Campus Benjamin Franklin, Clinical Research Centre of Women's Health, Hindenburgdamm 30, D-12200 Berlin, Germany

4 Correspondence address. Tel: + 49 30 8445 3227; Fax: + 49 30 8445 2352; E-mail: martina.doeren{at}charite.de

Knowledge about the impact of menopausal hormone therapy (MHT) on the risk of ovarian cancer (OvC) is insufficient, and studies are inconsistent. Mortality from OvC ranks highest among cancer sites in female reproductive organs. We performed meta-analyses to assess the impact of specified types of MHT on the risk of OvC in cohort studies (CS), case-control studies (CCS), randomized controlled trials (RCT) and cancer registry studies (CRS). We used data published 1966–2006 on estrogen therapy (ET), estrogen/progestin therapy (EPT) or MHT (unspecified regimen) identified by a structured, computerized and manual literature search. We identified 42 studies (30CCS, 7CS, 1 RCT and 4 CRS) with 12 238 cases. The risk of OvC (ever-use, annual risk) is increased 1.28-fold by ET [confidence interval (CI) 1.18–1.40] and 1.11-fold by EPT (CI 1.02–1.21) with a suggestion of greater risks with ET. There appears to be no differential impact of any therapy on histological subtypes. Risks were greater in European than North American studies for both ET and EPT. In conclusion, ET as well as EPT, are risk factors for OvC. Given the widespread use of MHT, known benefits should be weighed against the increased risk of OvC, and more studies are warranted, particularly on factors with the greatest apparent risks.

Key words: ovarian cancer / risk factor / estrogen (progestin) therapy / menopausal hormone therapy / hormone replacement therapy

Received on February 13, 2007; revised April 14, 2007; accepted on April 25, 2007


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol. Endocrinol.Home page
S.-H. Park, L. W. T. Cheung, A. S. T. Wong, and P. C. K. Leung
Estrogen Regulates Snail and Slug in the Down-Regulation of E-Cadherin and Induces Metastatic Potential of Ovarian Cancer Cells through Estrogen Receptor {alpha}
Mol. Endocrinol., September 1, 2008; 22(9): 2085 - 2098.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.