Human Reproduction Update, Vol.2, No.4 pp.345-353, 1996
© European Society of Human Reproduction and Embryology 1996; all rights reserved
The incidence of major clinical complications in a Dutch transport IVF programme
0 Department of Obstetrics and Gynaecology, Zuiderziekenhuis, Groene Hilledijk 315, 3075 EA Rotterdam, The Netherlands 2 Department of Endocrinology and Reproduction, Erasmus University, Dr Molewaterplein 50, 3015 GD Rotterdam, The Netherlands 1 Corresponding author
Abstract
Four different major clinical complications were identified in a retrospective analysis of 2495 in-vitro fertilization (IVF) cycles resulting in oocyte retrieval. The severe form of ovarian hyperstimulation syndrome (OHSS) occurred in 18 patients, giving a prevalence for this complication of 0.7%. Seven (39%) of these 18 patients had previously been diagnosed as having polycystic ovaries. Eleven patients were admitted with moderate OHSS. Adnexal torsion was diagnosed in two patients. Ovariectomy was considered necessary in both cases. Complications of the transvaginal procedure occurred in seven cases (0.3%): one patient had an acute appendicitis with puncture holes in the appendix, six patients were admitted shortly after oocyte retrieval with a pelvic inflammatory disease. Of the 624 pregnancies obtained, 13 were ectopic, giving an ectopic pregnancy rate of 2.1%. It is concluded that serious clinical complications of IVF treatment are rare. However, patients should be counselled for the occurrence of serious procedure-related complications before entering an IVF programme.
Keywords: clinical complications/ectopic pregnancy/IVF/OHSS
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