Human Reproduction Update, Vol.5, No.2 pp.108-119, 1999
© European Society of Human Reproduction and Embryology 1999; all rights reserved
Mini symposium. New aspects of spermatogenesis. Expression of mitochondrial marker proteins during spermatogenesis
Department of Anatomy and Cell Biology, Philipps-University of Marburg, Robert-Koch-Strasse 6, D-35037 Marburg, Germany 0 Corresponding author at: Institut für Anatomie und Zellbiologie, Robert-Koch-Strasse 6, D-35033 Marburg, Germany e-mail: seitz@mailer.uni-marburg.de
Abstract
Spermatogenesis is a highly complex, hormonally regulated cytodifferentiation process finally leading to the production of spermatozoa. In addition to other events germ cell differentiation is characterized by a gradual structural modification of many organelles including mitochondria which plays a unique role. The morphological and functional development of germ cell mitochondria is a reflection of the permanent change in the testicular microenvironment which occurs when the germ cells are slowly moving from the base of the seminiferous epithelium to the lumen. Concomitant with the structural changes, several mitochondrial proteins are known to be expressed and synthesized during distinct phases of the organelle's development. This review pays particular attention to these transiently expressed mitochondrial proteins such as hsp60, Lon protease, sulphydryl oxidase and cytochrome ct. Furthermore, the biological function of this stepwise gene activation during mitochondrial and germ cell development is discussed.
Keywords: chaperones/Lon protease/mitochondria/spermatogenesis/sulphydryl oxidase
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