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Human Reproduction Update, Vol.5, No.2 pp.166-171, 1999
© European Society of Human Reproduction and Embryology 1999; all rights reserved

Leptin, polycystic ovaries and polycystic ovary syndrome

HS Jacobs0 and GS Conway

Department of Endocrinology, UCL Medical School, The Middlesex Hospital, Mortimer Street, London W1N 8AA, UK 0 Corresponding author

Abstract

As soon as leptin was discovered four years ago, its potential as a player in the polycystic ovary syndrome (PCOS) was explored in a primitive way, though little light was shed on the enigma that is PCOS. As a second wave of leptin research is now available, we review how the expanded role of the cytokine in reproduction might yet impact upon our understanding of PCOS.

Keywords: insulin resistance/leptin/polycystic ovary syndrome/obesity


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