Human Reproduction Update, Vol.5, No.3 pp.223-233, 1999
© European Society of Human Reproduction and Embryology 1999; all rights reserved
Mini symposium. The major histocompatibility complex in pregnancy: Part II. Placental HLA-G protein expression in vivo: where and what for?
INSERM U395, CHU Purpan, BP 3028, 31024 Toulouse Cedex 3, France 0 Corresponding author Tel: +33 5 62 748 374 Fax: +33 5 61 319 752 E-mail: Philippe.Le-Bouteiller@purpan.inserm.fr
Abstract
In contrast to HLA-A and -B class Ia genes that are down-regulated in human trophoblast cells, HLA-G class Ib molecules are expressed in the placenta throughout gestation. In addition to extravillous cytotrophoblast that invade the decidua basalis essentially, HLA-G was also observed in endothelial cells of fetal vessels in the chorionic villi as well as in amnion cells and amniotic fluid. Both membrane-bound and soluble HLA-G isoforms have been detected. In view of the recently published functional data showing that HLA-G: (i) has the capability to bind and present peptides; (ii) is recognized by at least three different killing inhibitory receptors; and (iii) is a regulator of HLA-E expression, we can predict that such functions are likely to be exerted by extravillous cytotrophoblast. Of particular importance will be the anti-viral function of HLA-G at this materno-fetal interface, knowing that HLA-G was shown to be expressed by thymic medullary epithelial cells. In addition to these immunological functions, due to its presence on chorionic fetal endothelial cells, we hypothesize that HLA-G could also be a regulator of chorionic villous angiogenesis. Finally, soluble HLA-G isoforms may act as specific immunosuppressors during pregnancy.
Keywords:cytotoxic T cells/endothelial cells/HLA-G/NK cell receptors/trophoblast
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Helige, H. Ahammer, A. Hammer, B. Huppertz, H.-G. Frank, and G. Dohr Trophoblastic invasion in vitro and in vivo: similarities and differences Hum. Reprod., October 1, 2008; 23(10): 2282 - 2291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Barel, M. Ressing, N. Pizzato, D. van Leeuwen, P. Le Bouteiller, F. Lenfant, and E. J. H. J. Wiertz Human Cytomegalovirus-Encoded US2 Differentially Affects Surface Expression of MHC Class I Locus Products and Targets Membrane-Bound, but Not Soluble HLA-G1 for Degradation J. Immunol., December 15, 2003; 171(12): 6757 - 6765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Pavan, A. Tarrade, A. Hermouet, C. Delouis, M. Titeux, M. Vidaud, P. Therond, D. Evain-Brion, and T. Fournier Human invasive trophoblasts transformed with simian virus 40 provide a new tool to study the role of PPAR{gamma} in cell invasion process Carcinogenesis, August 1, 2003; 24(8): 1325 - 1336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Lenfant, N. Pizzato, S. Liang, C. Davrinche, P. Le Bouteiller, and A. Horuzsko Induction of HLA-G-restricted human cytomegalovirus pp65 (UL83)-specific cytotoxic T lymphocytes in HLA-G transgenic mice J. Gen. Virol., January 1, 2003; 84(2): 307 - 317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. Langat and J. S. Hunt Do Nonhuman Primates Comprise Appropriate Experimental Models for Studying the Function of Human Leukocyte Antigen-G? Biol Reprod, November 1, 2002; 67(5): 1367 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. P. Gobin, P. Biesta, J. E. M. de Steenwinkel, G. Datema, and P. J. Van den Elsen HLA-G Transactivation by cAMP-response Element-binding Protein (CREB). AN ALTERNATIVE TRANSACTIVATION PATHWAY TO THE CONSERVED MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS I REGULATORY ROUTES J. Biol. Chem., October 11, 2002; 277(42): 39525 - 39531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tarrade, K. Schoonjans, L. Pavan, J. Auwerx, C. Rochette-Egly, D. Evain-Brion, and T. Fournier PPAR{gamma}/RXR{alpha} Heterodimers Control Human Trophoblast Invasion J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 5017 - 5024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Ait-Azzouzene, S. Caucheteux, F. Tchang, J. Wantyghem, R. Moutier, A. Langkopf, M.-C. Gendron, and C. Kanellopoulos-Langevin Transgenic Major Histocompatibility Complex Class I Antigen Expressed in Mouse Trophoblast Affects Maternal Immature B Cells Biol Reprod, August 1, 2001; 65(2): 337 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kubo, Y. Sonoda, R. Muramatsu, and M. Usui Immunogenicity of Human Amniotic Membrane in Experimental Xenotransplantation Invest. Ophthalmol. Vis. Sci., June 1, 2001; 42(7): 1539 - 1546. [Abstract] [Full Text]
|
|
|
|
 |
|
 K.A. Pfeiffer, R. Fimmers, G. Engels, H. van der Ven, and K. van der Ven The HLA-G genotype is potentially associated with idiopathic recurrent spontaneous abortion Mol. Hum. Reprod., April 1, 2001; 7(4): 373 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Harton and J. P.-Y. Ting Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression Mol. Cell. Biol., September 1, 2000; 20(17): 6185 - 6194. [Full Text]
|
|
|
|
|
|
S. Fournel, M. Aguerre-Girr, X. Huc, F. Lenfant, A. Alam, A. Toubert, A. Bensussan, and P. Le Bouteiller Cutting Edge: Soluble HLA-G1 Triggers CD95/CD95 Ligand-Mediated Apoptosis in Activated CD8+ Cells by Interacting with CD8 J. Immunol., June 15, 2000; 164(12): 6100 - 6104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Goldman-Wohl, I. Ariel, C. Greenfield, J. Hanoch, and S. Yagel HLA-G expression in extravillous trophoblasts is an intrinsic property of cell differentiation: a lesson learned from ectopic pregnancies Mol. Hum. Reprod., June 1, 2000; 6(6): 535 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.S. Goldman-Wohl, I. Ariel, C. Greenfield, D. Hochner-Celnikier, J. Cross, S. Fisher, and S. Yagel Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia Mol. Hum. Reprod., January 1, 2000; 6(1): 88 - 95. [Abstract] [Full Text] [PDF]
|
|