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Human Reproduction Update, Vol.5, No.4 pp.356-364, 1999
© European Society of Human Reproduction and Embryology 1999; all rights reserved

Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role

M Wheatley0 and SR Hawtin

School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK 0 Corresponding author

Abstract

Many hormones that are central to normal reproductive functioning mediate their physiological effects by activating a receptor which belongs to the large family of G-protein-coupled receptors (GPCR). Members of this family of receptor proteins are usually glycosylated on extracellular domains. In recent years the role of this glycosylation in cells surface expression/protein folding, ligand recognition and receptor-effector coupling has been investigated. This review summarises current knowledge of the role of glycosylation in the functioning of the receptors for gonadotrophin-releasing hormone (GnRH), luteinizing hormone/human chorionic gonadotrophin (LH/HCG), follicle stimulating hormone (FSH), oxytocin (OT) and vasopressin (AVP).

Key words: glycosylation/glycohormone receptors/gonadotrophin-releasing hormone receptor/oxytocin receptor/vasopressin receptor


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