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Human Reproduction Update, Vol.5, No.5 pp.535-545, 1999
© European Society of Human Reproduction and Embryology 1999; all rights reserved

Stem cell factor/c-kit system in spermatogenesis

C Mauduit0,1, S Hamamah2 and M Benahmed0

0 INSERM U407, Faculté de Médecine Lyon-Sud, BP 12, F-69921, Oullins Cedex, France 2 Hôpital Antoine Béclère, 157, rue de la porte de Trivaux, BP 405, 92 141 Clamart cedex, France 1 Corresponding author Tel: (33) 4 78 86 31 17 Fax: (33) 4 78 86 31 16 E-mail: mauduit@lsgrsn1.univ-lyon1.fr

Abstract

One of the major unresolved questions with male infertility is the identification of the molecular origin of a great majority of the spermatogenetic arrests currently diagnosed as idiopathic male infertility. During the past years, several families of regulating factors are signalling molecules, and particularly the stem cell factor (SCF)/c-kit system. The SCF and its receptor c-kit are an appropriate example to illustrate the role of signalling molecules in the physiology and pathology of spermatogenesis. The SCF/c-kit regulates primordial germ cell migration, proliferation and apoptosis during fetal gonadal development. The SCF/c-kit also regulates spermatogonia proliferation in the adult animal. In mutant mice, abnormalities of the SCF/c-kit gene expression, such as gene deletion, point mutation, alternative splicing defect, lead to different types of spermatogenesis alterations (e.g. decrease in primordial germ cell migration, decrease in spermatogonia proliferation). More recently, defects in SCF/c-kit gene expression have also been shown in human testicular dysfunctions. Indeed, a reduction in SCF/c-kit expression has been evidenced in oligozoospermia/azoospermia associated with an increase in the germ cell apoptosis process. In addition, c-kit seems to be a good marker of seminoma testicular tumours. This review reports a large number of data - obtained essentially in animal models - that suggest an important role for the SCF/c-kit system in spermatogenesis and, as a corollary, its potential involvement in spermatogenic defects.

Key words: c-kit/germ cells/stem cell factor/testicular development/testis


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