Human Reproduction Update, Vol.6, No.1 pp.75-79, 2000
© European Society of Human Reproduction and Embryology 2000; all rights reserved
The role of HOX genes in human implantation
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, USA
Received on April 1, 1999; accepted September 9, 1999
Abstract
HOXgenes are transcriptional regulators that play an essential role in determining tissue identity during embryonic development. HOXgenes are involved in the development of the Müllerian system and then continue to be expressed in the adult uterus. Two HOX genes have been demonstrated necessary for uterine receptivity in knock-out mice. We have recently elucidated the expression patterns and regulation of HOX genes in the development of the human endometrium during the menstrual cycle. HOX genes are likely key regulators of human implantation. This paper will review the role of HOXgenes in the reproductive tract, specifically the evidence that HOXgenes are important for human endometrial development and receptivity.
Key words: endometrium/ / genes/ / homeobox/ / implantation/ / sex steroids
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