Human Reproduction Update, Vol.6, No.2 pp.169-176, 2000
© European Society of Human Reproduction and Embryology 2000; all rights reserved
The metabolic effect of antenatal corticosteroid therapy
Section of Obstetrics and Gynaecology, Imperial College School of Medicine at Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
Received on September 28, 1999; accepted on January 21, 2000
Abstract
The use of antenatal dexamethasone to mature the fetal lung in pregnancies likely to deliver before 34 weeks is almost universal. It reduces the incidence of respiratory distress syndrome in the newborn and results in an overall improvement in neonatal morbidity and mortality. Although considered to be generally safe, there are concerns about adverse maternal and fetal effects. In a series of studies, we have found that antenatal dexamethasone administration is associated with reduced placental hormone production and maternal bone formation, impaired glucose tolerance and altered function of the hypothalamic–pituitary–adrenal axis. In this article, we have compared our data with other reports in the human and reviewed the relevant animal data. We conclude that further studies on the long-term effects of antenatal dexamethasone therapy in the human are warranted with particular emphasis on the long-term effects on the fetus.
Key words: antenatal corticosteroids/ / dexamethasone/ / fetal growth/ / metabolic effects/ / respiratory distress