Human Reproduction Update, Vol.6, No.5 pp.495-504, 2000
© European Society of Human Reproduction and Embryology 2000; all rights reserved
Insulin-like growth factor binding protein-1 (IGFBP-1): a multifunctional role in the human female reproductive tract
1 Harris Birthright Research Centre for Fetal Medicine, Department of Obstetrics and Gynaecology, King’s College Hospital, London 2 Department of Medicine, Guy’s, King’s and St Thomas’ Medical School, London, UK
To whom correspondence should be addressed at: D. J. Fowler, Genetics Unit, Massachusetts General Hospital, 55 Fruit Street, Warren 801, Boston, Massachusetts 02114-2696, USA. Tel: 00-1-617-726-1742; Fax: 00-1-617-724-1911; e-mail: djfowler{at}partners.org
Abstract
Insulin-like growth factor-1 (IGFBP-1) is particularly important in human female reproductive physiology, where it is involved with other factors in a complex system which regulates menstrual cycles, puberty, ovulation, decidualization, implantation and fetal growth. This has implications for clinical obstetrics and gynaecology, where there is evidence for a pathophysiological role for IGFBP-1 in pre-eclampsia, intrauterine growth restriction, polycystic ovarian syndrome and trophoblast and endometrial neoplasms.
Key words: female reproductive tract / IGFBP-1 / intrauterinegrowth restriction / polycystic ovarian syndrome / pre-eclampsia
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