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Human Reproduction Update, Vol.6, No.5 pp.519-529, 2000
© European Society of Human Reproduction and Embryology 2000; all rights reserved

The regulation of the human corpus luteum steroidogenesis: a hypothesis?

V. J. H. Oon1 and M. R. Johnson1

1 Imperial College School of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK

To whom correspondence should be addressed at: M. R. Johnson, Department of Maternal Fetal Medicine, Division of Paediatrics, Obstetrics and Gynaecology, Imperial College School of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK. Phone: +44 020 8846 7887; Fax: +44 020 8846 7796; e-mail: mark.johnson{at}ic.ac.uk

Abstract

The corpus luteum (CL) is an important endocrine organ in the menstrual cycle and in pregnancy. The regulation of its hormonal production has been extensively studied. The steroidogenic abilities of the CL can be rescued by human chorionic gonadotrophin (HCG) but its role in the maintenance of CL function is not clear. We will discuss the hypothesis that there are fetoplacental factors, other than HCG, that modulate CL steroidogenesis.

Key words: corpus luteum / feto–placental factors / human chorionic gonadotrophins / pregnancy / steroidogenesis


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