Human Reproduction Update, Vol.7, No.4 pp.370-377, 2001
© European Society of Human Reproduction and Embryology 2001; all rights reserved
Sperm banking and assisted reproduction treatment for couples following cancer treatment of the male partner
1 Bourn Hall Clinic, Bourn, Cambridge CB3 7TR, UK
To whom correspondence should be addressed at: Amir Lass, Serono Pharmaceuticals Ltd., Bedfont Cross, Stanwell Road, Feltham, Middlesex TW14 8NX, UK. e-mail: amir.lass{at}serono.com
Abstract
In recent years, the survival of young males suffering from cancer has been improved. Development of new techniques such as IVF and intracytoplasmic sperm injection enables even low quality spermatozoa to be used successfully. It is possible therefore to preserve fertility potential of cancer patients before embarking on adjuvant chemotherapy and radiotherapy. Recognizing the importance of protecting the fertility potential of these young males, we present our recommendations for sperm cryopreservation based on the 11 year experience of Bourn Hall and the British Joint Council for Clinical Oncology consultation report. This paper discusses the options available for patients who recover from cancer to become fathers. In many cases patients are concerned about possible abnormalities and teratogenic risks to their future children who have been conceived naturally or by fertility treatment. The data available in the literature may reassure the medical community that there is no such increased risk. However, due to the relatively small number of children born after such treatment, a long-term follow-up is required. There is an ongoing debate regarding the justification for the programme due to the small number of patients who make use of their banked spermatozoa. The authors believe in the importance of protecting the fertility potential of cancer patients, enabling them to father their genetic children in the future while fighting their illness.
Key words: assisted reproductive techniques / cancer / chemotherapy / semen cryopreservation
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Tschudin and J. Bitzer Psychological aspects of fertility preservation in men and women affected by cancer and other life-threatening diseases Hum. Reprod. Update, September 1, 2009; 15(5): 587 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Hart Preservation of fertility in adults and children diagnosed with cancer BMJ, October 27, 2008; 337(oct27_1): a2045 - a2045. [Full Text]
|
|
|
|
 |
|
 M. Braun and L. Baider Souvenir Children: Death and Rebirth J. Clin. Oncol., December 1, 2007; 25(34): 5525 - 5527. [Full Text] [PDF]
|
|
|
|
 |
|
 B. N. Savani, E. Kozanas, A. Shenoy, A. J. Barrett, A. Rovo, A. Tichelli, A. Gratwohl, and C. De Geyter Recovery of spermatogenesis after total-body irradiation Blood, December 15, 2006; 108(13): 4292 - 4294. [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Copelan Hematopoietic stem-cell transplantation. N. Engl. J. Med., April 27, 2006; 354(17): 1813 - 1826. [Full Text] [PDF]
|
|
|
|
 |
|
 V. Keros, B. Rosenlund, K. Hultenby, L. Aghajanova, L. Levkov, and O. Hovatta Optimizing cryopreservation of human testicular tissue: comparison of protocols with glycerol, propanediol and dimethylsulphoxide as cryoprotectants Hum. Reprod., June 1, 2005; 20(6): 1676 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Agarwal and S. S. R. Allamaneni Disruption of Spermatogenesis by the Cancer Disease Process J Natl Cancer Inst Monographs, March 1, 2005; 2005(34): 9 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Shin, K. C. Lo, and L. I. Lipshultz Treatment Options for the Infertile Male With Cancer J Natl Cancer Inst Monographs, March 1, 2005; 2005(34): 48 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kanatsu-Shinohara, N. Ogonuki, K. Inoue, A. Ogura, S. Toyokuni, and T. Shinohara Restoration of fertility in infertile mice by transplantation of cryopreserved male germline stem cells Hum. Reprod., December 1, 2003; 18(12): 2660 - 2667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shinohara, K. Inoue, N. Ogonuki, M. Kanatsu-Shinohara, H. Miki, K. Nakata, M. Kurome, H. Nagashima, S. Toyokuni, K. Kogishi, et al. Birth of offspring following transplantation of cryopreserved immature testicular pieces and in-vitro microinsemination Hum. Reprod., December 1, 2002; 17(12): 3039 - 3045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Schover, K. Brey, A. Lichtin, L. I. Lipshultz, and S. Jeha Oncologists' Attitudes and Practices Regarding Banking Sperm Before Cancer Treatment J. Clin. Oncol., April 1, 2002; 20(7): 1890 - 1897. [Abstract] [Full Text] [PDF]
|
|