Human Reproduction Update, Vol.7, No.6 pp.547-555, 2001
© European Society of Human Reproduction and Embryology 2001; all rights reserved
Peritoneal repair and post-surgical adhesion formation
1 Department of Obstetrics & Gynecology, University of Southern California Keck School of Medicine, Department of Obstetrics and Gynecology, Livingston Reproductive Biology Laboratories, 1321 North Mission Road, Los Angeles, CA 90033, USA
To whom correspondence should be addressed at: Gere S. diZerega, Department of Obstetrics & Gynecology, University of Southern California Keck School of Medicine, Department of Obstetrics and Gynecology, Livingston Reproductive Biology Laboratories, 1321 North Mission Road, Los Angeles, CA 90033, USA. e-mail: GSD1270{at}aol.com
Abstract
It was shown in 1919 that peritoneal healing differs from that of skin. When a defect is made in the parietal peritoneum the entire surface becomes epithelialized simultaneously and not gradually from the borders as in epidermalization of skin wounds. While multiplication and migration of mesothelial cells from the margin of the wound may play a small part in the regenerative process, it cannot play a major role, since new mesothelium develops in the centre of a large wound at the same time as it develops in the centre of a smaller one. Development of intraperitoneal adhesions is a dynamic process whereby surgically traumatized tissues in apposition bind through fibrin bridges which become organized by wound repair cells, often supporting a rich vascular supply as well as neuronal elements
Key words: mesothelial cells / peritoneal repair / post-surgical adhesion / wound repair
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