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Human Reproduction Update, Vol.8, No.6 pp.523-527, 2002
© European Society of Human Reproduction and Embryology 2002; all rights reserved

Culture of fetal cells from maternal blood for prenatal diagnosis

Hélène A. Elicha Gussin1 and Sherman Elias1,2

1 University of Illinois at Chicago, Departments of Obstetrics and Gynecology, 2 Molecular Genetics, Chicago, Illinois, USAselias@uic.edu

To whom correspondence should be addressed at: Sherman Elias, University of Illinois at Chicago, Department of Obstetrics and Gynecology, 820 S. Wood Street, M/C 808, Chicago IL 60612, USA; e-mail: selias{at}uic.edu

Abstract

The isolation and analysis of fetal cells from maternal blood would allow non-invasive prenatal genetic screening and diagnosis. Over the past decade, progress has been made towards this goal using various enrichment strategies and analysis by fluorescence in-situ hybridization with chromosome-specific probes and PCR. One method that is currently being explored involves culturing fetal cells. Developing conditions which allow the number of fetal-derived cells to expand in culture and the number of maternally derived cells to be suppressed in culture may lead to a new selection process for obtaining fetal cells. Culturing of fetal cells from maternal blood could make possible conventional metaphase analysis of fetal cells for diagnosis of chromosomal abnormalities.

Key words: cell culture / maternal circulation / pregnancy / prenatal diagnosis


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