Human Reproduction Update Advance Access published online on June 2, 2008
Human Reproduction Update, doi:10.1093/humupd/dmn012
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Current evidence on surgery, systemic methotrexate and expectant management in the treatment of tubal ectopic pregnancy: a systematic review and meta-analysis
1 Department of Obstetrics and Gynaecology, Academic Medical Centre, PO Box 22700, 1100 DE Amsterdam, The Netherlands 2 Centre for Reproductive Medicine, Academic Medical Centre, PO Box 22700, 1100 DE Amsterdam, The Netherlands
To whom correspondence should be addressed at: 3Correspondence address: Tel: +31-20-5663654; Fax: +31-20-6963489; E-mail: f.mol{at}amc.nl
BACKGROUND: To evaluate the effectiveness of surgery, medical treatment and expectant management of tubal ectopic pregnancy (EP) in terms of treatment success (i.e. complete elimination of trophoblast tissue), financial costs and future fertility.
METHODS: We searched for randomized controlled trials which described treatment interventions that have been widely adopted in clinical practice. A systemic literature search identified 15 trials.
RESULTS: Laparoscopic salpingostomy was significantly less successful than the open surgical approach (relative risk, RR 0.9, 95% CI 0.82–0.99) due to a higher persistent trophoblast rate, but was significantly less costly. A prophylactic single shot methotrexate (MTX), given intramuscularly (i.m.) immediately post-operatively, significantly reduced persistent trophoblast after laparoscopic salpingostomy (RR 0.89, 95% CI 0.82–0.98, number needed to treat of 10). With systemic MTX in a fixed multiple dose i.m. regimen the likelihood of treatment success was higher than with laparoscopic salpingostomy (RR 1.15, 95% CI 0.93–1.43), but the difference was not significant. Systemic MTX in a fixed multiple dose i.m. regimen was only cost–effective if serum human chorionic gonadotrophin (hCG) concentrations were <3000 IU/l. If serum hCG concentrations were <1500 IU/l, then the single-dose MTX i.m. regimen—if necessary with additional MTX injections—was also cost–effective. Expectant management could not be evaluated yet. Subsequent fertility did not differ between the interventions studied.
CONCLUSIONS: This meta-analysis shows that laparoscopic surgery is the most cost–effective treatment for tubal EP. Systemic MTX is a good alternative in selected patients with low serum hCG concentrations.
Key words: ectopic pregnancy / laparoscopy / cost effectiveness / trophoblast
Received on October 5, 2007; revised January 16, 2008; accepted on March 28, 2008
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