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Human Reproduction Update Advance Access originally published online on September 29, 2008
Human Reproduction Update 2008 14(6):541-542; doi:10.1093/humupd/dmn039
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Ovulation suppression to protect against chemotherapy-induced ovarian toxicity: helpful or just hopeful?

Edward G. Hughes1,3 and Michael S. Neal2,3

1 Department of Obstetrics and Gynecology 2 Reproductive Biology Division, McMaster University 3 Centre for Reproductive Care, Hamilton Health Sciences, Hamilton, Ontario, Canada

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"The whole of medicine depends on the transparent reporting of clinical trials".

Drummond Rennie

For many years, young men with cancer have successfully stored sperm for assisted conception after curative treatment. It is now increasingly common for young women to seek fertility care before embarking on potentially gonadotoxic chemotherapy or irradiation treatment. The two reviews reported in this issue of Human Reproduction Update ask primarily whether, for these women, ovarian suppression with gonadotrophin-releasing hormone analogues (GnRHa) improves the prognosis for future fertility (Beck-Fruchter et al., 2008Go; Blumenfeld and von Wolff, 2008Go).

The options for fertility preservation in female cancer patients currently include ovulation suppression and cryopreservation of reproductive tissue. The most reliable choice remains embryo freezing . . . [Full Text of this Article]


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