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Human Reproduction Update Advance Access published online on October 27, 2009
Human Reproduction Update, doi:10.1093/humupd/dmp043
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Reply to Heparin's ‘potential to improve pregnancy rates and outcomes’ is not evidence-based

Scott M. Nelson1 and Ian A. Greer2

1 Reproductive & Maternal Medicine, Faculty of Medicine, University of Glasgow, Glasgow, UK 2 Faculty of Medicine, The Hull York Medical School, Heslington York, UK

The first 10% of the full text of this article appears below.

Sir,

We would like to thank Ricci et al. for their interesting comments. Firstly they suggest that at present there is insufficient evidence to support the use of heparin in women with recurrent implantation failure and thrombophilia. We agree that the trial data as summarized by us and substantiated by Ricci and colleagues are limited (Nelson and Greer, 2008). In the context of our review, we therefore highlighted repeatedly the necessity for further adequately powered randomized controlled trials to address this important clinical question. Specifically, we stated that ‘Further study of heparin, both in terms of mode of action and its potential therapeutic role in women with thrombophilia and implantation failure are warranted, . . . [Full Text of this Article]


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Related articles in Human Reproduction Update:

Heparin's ‘potential to improve pregnancy rates and outcomes’ is not evidence-based
Giuseppe Ricci, Elena Giolo, and Roberto Simeone
Human Reproduction Update 2009 10.1093/humupd/dmp044. [Extract] [Full Text]