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Human Reproduction Update Advance Access originally published online on April 7, 2005
Human Reproduction Update 2005 11(3):205-214; doi:10.1093/humupd/dmi010
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

Biological basis for human capacitation

Christopher De Jonge

Reproductive Medicine Center, University of Minnesota, 606, 24th Avenue South, Suite 500, Minneapolis, MN 55454, USA. Email: dejonge{at}umn.edu

More than 50 years ago Austin and Chang defined mammalian sperm capacitation as a period of time that sperm must reside in the female reproductive tract before they acquire the ability to fertilize oocytes. Since then numerous investigations have attempted to more clearly define the molecules and processes that are a part of capacitation. The data that have provided a more clear definition of capacitation were primarily derived from in vitro experiments. This is particularly true for studies on human sperm capacitation. While ethical constraints have limited an equal balance of in vivo studies there are those data that when coupled with some of the in vitro data allow for the formulation of a biological framework for human sperm capacitation in vivo. This review will put forth the biological basis for human capacitation.

Key words: female tract / fertilization / in vivo capacitation / signal transduction sperm capacitation mechanisms


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