Human Reproduction Update Advance Access originally published online on July 8, 2005
Human Reproduction Update 2005 11(5):461-471; doi:10.1093/humupd/dmi020
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Regulation of primordial follicle assembly and development
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA, USA
To whom correspondence should be addressed at: Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4231, USA. E-mail: Skinner{at}mail.wsu.edu
The assembly of the primordial follicles early in ovarian development and the subsequent development and transition of the primordial follicle to the primary follicle are critical processes in ovarian biology. These processes directly affect the number of oocytes available to a female throughout her reproductive life. Once the pool of primordial follicles is depleted a series of physiological changes known as menopause occur. The inappropriate coordination of these processes contributes to ovarian pathologies such as premature ovarian failure (POF) and infertility. Primordial follicle assembly and development are coordinated by locally produced paracrine and autocrine growth factors. Endocrine factors such as progesterone have also been identified that influence follicular assembly. Locally produced factors that promote the primordial to primary follicle transition include growth factors such as kit ligand (KL), leukaemia inhibitory factor (LIF), bone morphogenic proteins (BMP’s), keratinocyte growth factor (KGF) and basic fibroblast growth factor (bFGF). Factors mediating both precursor theca–granulosa cell interactions and granulosa–oocyte interactions have been identified. A factor produced by preantral and antral follicles, Müllerian inhibitory substance, can act to inhibit the primordial to primary follicle transition. Observations suggest that a complex network of cell–cell interactions is required to control the primordial to primary follicle transition. Elucidation of the molecular and cellular control of primordial follicle assembly and the primordial to primary follicle transition provides therapeutic targets to regulate ovarian function and treat ovarian disease.
Key words: granulosa / growth factors / ovary / primordial follicle / theca
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G.M. Hartshorne, S. Lyrakou, H. Hamoda, E. Oloto, and F. Ghafari Oogenesis and cell death in human prenatal ovaries: what are the criteria for oocyte selection? Mol. Hum. Reprod., December 1, 2009; 15(12): 805 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.H. Dickerson, L.W. Cho, S.D. Maguiness, S.L. Killick, J. Robinson, and S.L. Atkin Insulin resistance and free androgen index correlate with the outcome of controlled ovarian hyperstimulation in non-PCOS women undergoing IVF Hum. Reprod., November 17, 2009; (2009) dep393v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Edson, A. K. Nagaraja, and M. M. Matzuk The Mammalian Ovary from Genesis to Revelation Endocr. Rev., October 1, 2009; 30(6): 624 - 712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Nilsson, G. Dole, and M. K Skinner Neurotrophin NT3 promotes ovarian primordial to primary follicle transition Reproduction, October 1, 2009; 138(4): 697 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ruoss, A. Tadros, T. O'Shea, J. McFarlane, and G. Almahbobi Ovarian follicle development in Booroola sheep exhibiting impaired bone morphogenetic protein signalling pathway Reproduction, October 1, 2009; 138(4): 689 - 696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Liu, D. G. de Matos, H.-Y. Fan, M. Shimada, S. Palmer, and J. S. Richards Interleukin-6: An Autocrine Regulator of the Mouse Cumulus Cell-Oocyte Complex Expansion Process Endocrinology, July 1, 2009; 150(7): 3360 - 3368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. N. Harvey, M. Esmail, Q. Wang, A. I. Brooks, R. Zachow, and M. Uzumcu Effect of the Methoxychlor Metabolite HPTE on the Rat Ovarian Granulosa Cell Transcriptome In Vitro Toxicol. Sci., July 1, 2009; 110(1): 95 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Matos, D. Stevenson, F. Gomes, J.L. Silva-Carvalho, and H. Almeida Superoxide dismutase expression in human cumulus oophorus cells Mol. Hum. Reprod., July 1, 2009; 15(7): 411 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Nicholas, S. L. Chavez, V. L. Baker, and R. A. Reijo Pera Instructing an Embryonic Stem Cell-Derived Oocyte Fate: Lessons from Endogenous Oogenesis Endocr. Rev., May 1, 2009; 30(3): 264 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Fowler, S. Flannigan, A. Mathers, K. Gillanders, R. G. Lea, M. J. Wood, A. Maheshwari, S. Bhattacharya, E. S. R. Collie-Duguid, P. J. Baker, et al. Gene Expression Analysis of Human Fetal Ovarian Primordial Follicle Formation J. Clin. Endocrinol. Metab., April 1, 2009; 94(4): 1427 - 1435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Rodrigues, D. Limback, L. K McGinnis, C. E Plancha, and D. F Albertini Multiple mechanisms of germ cell loss in the perinatal mouse ovary Reproduction, April 1, 2009; 137(4): 709 - 720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A McLaughlin and S. C McIver Awakening the oocyte: controlling primordial follicle development Reproduction, January 1, 2009; 137(1): 1 - 11. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Andreu-Vieyra, R. Chen, and M. M. Matzuk Conditional Deletion of the Retinoblastoma (Rb) Gene in Ovarian Granulosa Cells Leads to Premature Ovarian Failure Mol. Endocrinol., September 1, 2008; 22(9): 2141 - 2161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I.-S. Hong, A. P. Cheung, and P. C. K. Leung Gonadotropin-Releasing Hormones I and II Induce Apoptosis in Human Granulosa Cells J. Clin. Endocrinol. Metab., August 1, 2008; 93(8): 3179 - 3185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M Seneda, M. Godmann, B. D Murphy, S. Kimmins, and V. Bordignon Developmental regulation of histone H3 methylation at lysine 4 in the porcine ovary Reproduction, June 1, 2008; 135(6): 829 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Franks, J. Stark, and K. Hardy Follicle dynamics and anovulation in polycystic ovary syndrome Hum. Reprod. Update, May 22, 2008; (2008) dmn015v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Dole, E. E Nilsson, and M. K Skinner Glial-derived neurotrophic factor promotes ovarian primordial follicle development and cell-cell interactions during folliculogenesis Reproduction, May 1, 2008; 135(5): 671 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. De La Chesnaye, B. Kerr, A. Paredes, H. Merchant-Larios, J. P. Mendez, and S. R. Ojeda Fbxw15/Fbxo12J Is an F-Box Protein-Encoding Gene Selectively Expressed in Oocytes of the Mouse Ovary Biol Reprod, April 1, 2008; 78(4): 714 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. C. Strohsnitter, E. E. Hatch, M. Hyer, R. Troisi, R. H. Kaufman, S. J. Robboy, J. R. Palmer, L. Titus-Ernstoff, D. Anderson, R. N. Hoover, et al. The Association between In Utero Cigarette Smoke Exposure and Age at Menopause Am. J. Epidemiol., March 15, 2008; 167(6): 727 - 733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Livera, B. Petre-Lazar, M.-J. Guerquin, E. Trautmann, H. Coffigny, and R. Habert p63 null mutation protects mouse oocytes from radio-induced apoptosis Reproduction, January 1, 2008; 135(1): 3 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Zachow and M. Uzumcu The hepatocyte growth factor system as a regulator of female and male gonadal function J. Endocrinol., December 1, 2007; 195(3): 359 - 371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Nilsson, N. Rogers, and M. K Skinner Actions of anti-Mullerian hormone on the ovarian transcriptome to inhibit primordial to primary follicle transition Reproduction, August 1, 2007; 134(2): 209 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-M. Dolmans, B. Martinez-Madrid, E. Gadisseux, Y. Guiot, W. Y. Yuan, A. Torre, A. Camboni, A. Van Langendonckt, and J. Donnez Short-term transplantation of isolated human ovarian follicles and cortical tissue into nude mice Reproduction, August 1, 2007; 134(2): 253 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, J. Li, C. Ying Wang, A. H. Yan Kwok, and F. C. Leung Epidermal Growth Factor (EGF) Receptor Ligands in the Chicken Ovary: I. Evidence for Heparin-Binding EGF-Like Growth Factor (HB-EGF) as a Potential Oocyte-Derived Signal to Control Granulosa Cell Proliferation and HB-EGF and Kit Ligand Expression Endocrinology, July 1, 2007; 148(7): 3426 - 3440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B John, L. J Shirley, T. D Gallardo, and D. H Castrillon Specificity of the requirement for Foxo3 in primordial follicle activation Reproduction, May 1, 2007; 133(5): 855 - 863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Marca and A. Volpe The Anti-Mullerian hormone and ovarian cancer Hum. Reprod. Update, May 1, 2007; 13(3): 265 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Garcia-Rudaz, F. Luna, V. Tapia, B. Kerr, L. Colgin, F. Galimi, G. A. Dissen, N. D. Rawlings, and S. R. Ojeda Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis Development, March 1, 2007; 134(5): 945 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Lucy The bovine dominant ovarian follicle J Anim Sci, March 1, 2007; 85(13_suppl): E89 - E99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Roberts, L. K. Arbogast, C. I. Friedman, D. E. Cohn, P. T. Kaumaya, and D. R. Danforth Neutralization of Endogenous Vascular Endothelial Growth Factor Depletes Primordial Follicles in the Mouse Ovary Biol Reprod, February 1, 2007; 76(2): 218 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ehmcke, B. Joshi, S. D Hergenrother, and S. Schlatt Aging does not affect spermatogenic recovery after experimentally induced injury in mice Reproduction, January 1, 2007; 133(1): 75 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Moniruzzaman, K. Sakamaki, Y. Akazawa, and T. Miyano Oocyte growth and follicular development in KIT-deficient Fas-knockout mice Reproduction, January 1, 2007; 133(1): 117 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Meduri, N. Massin, J. Guibourdenche, A. Bachelot, O. Fiori, F. Kuttenn, M. Misrahi, and P. Touraine Serum anti-Mullerian hormone expression in women with premature ovarian failure Hum. Reprod., January 1, 2007; 22(1): 117 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vaccari, S. Latini, M. Barberi, A. Teti, M. Stefanini, and R. Canipari Characterization and expression of different pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide receptors in rat ovarian follicles. J. Endocrinol., October 1, 2006; 191(1): 287 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G Knight and C. Glister TGF-{beta} superfamily members and ovarian follicle development. Reproduction, August 1, 2006; 132(2): 191 - 206. [Abstract] [Full Text] [PDF]
|
|