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Human Reproduction Update Advance Access originally published online on November 11, 2006
Human Reproduction Update 2007 13(2):197-206; doi:10.1093/humupd/dml052
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Reproduction and fertility in human immunodeficiency virus type-1 infection

E. van Leeuwen1,2,4, J.M. Prins2, S. Jurriaans3, K. Boer1, P. Reiss2, S. Repping1 and F. van der Veen1

1 Department of Obstetrics and Gynaecology, Centre for Reproductive Medicine, 2 Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS and Centre for Infection and Immunity Amsterdam (CINIMA) and 3 Department of Medical Microbiology, Academic Medical Centre, Amsterdam, The Netherlands

4 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Academic Medical Centre, H4-205, Meibergdreef 9, 1100 DD Amsterdam, The Netherlands. E-mail: e.vanleeuwen{at}amc.uva.nl


  Abstract

Human immunodeficiency virus type-1 (HIV-1) affects mostly men and women in their reproductive years. For those who have access to highly active antiretroviral therapy (HAART), the course of HIV-1 infection has shifted from a lethal to a chronic disease. As a result of this, many patients with HIV-1 consider having offspring, as do other patients of reproductive age with chronic illnesses. This article summarizes the current knowledge on the presence of HIV in the male and female genital tract, the effects of HIV-1 infection and HAART on male and female fertility and the results of various assisted reproduction techniques (ART) in HIV-1-infected men and women who wish to have offspring.

Key words: human immunodeficiency virus type-1 / infertility / swim up / antiretroviral therapy / assisted reproduction techniques

Received on July 11, 2006; revised September 29, 2006; accepted on October 10, 2006


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