Human Reproduction Update Advance Access originally published online on September 28, 2007
Human Reproduction Update 2008 14(1):15-25; doi:10.1093/humupd/dmm030
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Health-related quality of life measurement in women with polycystic ovary syndrome: a systematic review
1 Health Services Research Section, ScHARR, University of Sheffield, Regent Court, 30 Regent Street, Sheffield S1 4DA, UK 2 University of Sheffield School of Medicine and Biomedical Sciences, Beech Hill Road, Sheffield S10 2RX, UK 3 Department of Obstetrics and Gynaecology, Department of Reproductive Medicine and Surgery, United Leeds Teaching Hospitals, Clarendon Wing, Leeds General Infirmary, Leeds LS2 9NS, UK 4 Academic Unit of Reproductive and Developmental Medicine, Jessop Wing Hospital, Tree Root Walk, Sheffield S10 2TJ, UK
5 Correspondence address. Tel: +44-114-2220806; Fax: +44-114-2422136; E-mail: g.l.jones{at}sheffield.ac.uk
The symptoms typically associated with polycystic ovary syndrome (PCOS) such as acne, hirsutism, irregular menses, amenorrhoea, obesity and subfertility are a major source of psychological morbidity and can negatively affect quality of life (QoL). We systematically searched the literature to identify the impact of symptoms and treatments for PCOS on health-related QoL (HRQoL) and to report on the types and psychometric properties of the instruments used. Papers were retrieved by systematically searching four electronic databases and hand searching relevant reference lists and bibliographies. Nineteen papers used a standardized questionnaire to measure health status; of these 12 (63.2%) used generic tools and 8 (42%) used the disease-specific PCOS questionnaire. Although a meta-analysis was not possible, it appears that weight concerns have a particular negative impact upon HRQoL, although the role of body mass index in affecting HRQoL scores is inconclusive from the available evidence. Acne is the area least reported upon in terms of its impact upon HRQoL. With the exception of three studies, most of the research has focused upon adult women with PCOS. Despite the benefits of HRQoL measures in research, few are being used to evaluate the outcomes of treatment for PCOS upon the subjective health status of women with the condition.
Key words: health-related quality of life / polycystic ovary syndrome
Received on May 10, 2007; revised July 17, 2007; accepted on August 21, 2007
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