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Human Reproduction Update Advance Access originally published online on June 2, 2008
Human Reproduction Update 2008 14(4):391-392; doi:10.1093/humupd/dmn019
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Progesterone elevation on the day of hCG: methodological issues

Richard Fleming1

Glasgow Centre for Reproductive Medicine, Glasgow, UK

1 Correspondence address. E-mail: richard.fleming@gcrm.co.uk

The first 10% of the full text of this article appears below.

Sir,

Two recent interesting and learned articles in Human Reproduction Update concerning elevations of progesterone (P) in the follicular phase of controlled ovarian stimulation (Venetis et al., 2007Go; Bosch, 2008) address a number of issues which deserve further comment. The comments relate to technical issues (steroid hormone measurement and study design) as well as biological/biochemical concepts.

Both articles addressed specific critical concentration points of P in the follicular phase, and Bosch indicated the imprecise nature of selecting a single value (0.9 ng/ml). If we first set aside the debate over specific concentrations of circulating P demonstrating negative clinical consequences, presumably through advancing endometrial development, we must consider whether the assays used are reliable at the values observed. Most commercial assays were developed to determine the standard clinical question for the clinical biochemistry . . . [Full Text of this Article]


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