Human Reproduction Update, Vol.2, No.4 pp.323-335, 1996
© European Society of Human Reproduction and Embryology 1996; all rights reserved
The role of ultrasonography in the evaluation of endometrial receptivity following assisted reproductive treatments: a critical review
0 IVF and Infertility Unit, Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, 70300 Zerifin, Israel 2 Hadassah Hebrew University Medical School, Ein-Kerem, Jerusalem, Israel 1 Corresponding author
Abstract
We set out to estimate the value of ultrasonographic parameters as prognostic indicators of implantation following in-vitro fertilization (IVF) and embryo transfer. Our survey included 414 natural cycles, 3558 cycles following ovarian stimulation for IVF and embryo transfer, and 411 cycles with hormone replacement therapy for oocyte donation, reviewing 27 reports identified in a computerized literature research. The ultrasonographic prognostic indicators for implantation evaluated included peri-ovulatory endometrial thickness and pattern and Doppler measurements of uterine artery blood flow. Topics include: definitions of the ultrasonographic parameters proposed to evaluate uterine receptivity; the clinical context in which they were used; the proposed optimal timing for sonographic evaluation; and, finally, their actual correlation with pregnancy rate following assisted reproductive technologies. For various sonographic parameters, negative predictive value, positive predictive value, sensitivity and specificity were calculated, based on published data. Sonographic parameters had a high negative predictive value and sensitivity, but a limited positive predictive value and low specificity. Several confounding factors may influence the interpretation of reports, and the statistical evaluation sometimes lacks calculation of the positive and negative predictive values of the parameters examined. Although ultrasonographic parameters of endometrial receptivity have a strong negative value in setting some minimum criteria, their value as prognostic indicators for implantation following embryo transfer has yet to be proved.
Keywords: endometrial pattern/endometrial receptivity/endometrial thickness/uterine Doppler/uterine sonography
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Haouzi, S. Assou, K. Mahmoud, S. Tondeur, T. Reme, B. Hedon, J. De Vos, and S. Hamamah Gene expression profile of human endometrial receptivity: comparison between natural and stimulated cycles for the same patients Hum. Reprod., June 1, 2009; 24(6): 1436 - 1445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Jimenez-Krassel, J.K. Folger, J.L.H. Ireland, G.W. Smith, X. Hou, J.S. Davis, P. Lonergan, A.C.O. Evans, and J.J. Ireland Evidence That High Variation in Ovarian Reserves of Healthy Young Adults Has a Negative Impact on the Corpus Luteum and Endometrium During Estrous Cycles in Cattle Biol Reprod, June 1, 2009; 80(6): 1272 - 1281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Haapsamo, H. Martikainen, and J. Rasanen Low-dose aspirin and uterine haemodynamics on the day of embryo transfer in women undergoing IVF/ICSI: a randomized, placebo-controlled, double-blind study Hum. Reprod., April 1, 2009; 24(4): 861 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. H. Y. Ng, C. C. W. Chan, O. S. Tang, and P. C. Ho Comparison of 2-Dimensional, 3-Dimensional, and Vascular Ultrasonographic Parameters for Endometrial Receptivity Between 2 Consecutive Stimulated In Vitro Fertilization Cycles J. Ultrasound Med., July 1, 2007; 26(7): 931 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Y. Ng, C. C. W. Chan, O. S. Tang, W. S. B. Yeung, and P. C. Ho Endometrial and subendometrial vascularity is higher in pregnant patients with livebirth following ART than in those who suffer a miscarriage Hum. Reprod., April 1, 2007; 22(4): 1134 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Palomba, T. Russo, F. Orio Jr, A. Falbo, F. Manguso, A. Sammartino, A. Tolino, A. Colao, E. Carmina, and F. Zullo Uterine effects of clomiphene citrate in women with polycystic ovary syndrome: a prospective controlled study Hum. Reprod., November 1, 2006; 21(11): 2823 - 2829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Y. Ng, C. C. W. Chan, O. S. Tang, W. S. B. Yeung, and P. C. Ho The role of endometrial and subendometrial vascularity measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during frozen-thawed embryo transfer cycles Hum. Reprod., June 1, 2006; 21(6): 1612 - 1617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Y. Ng, C. C. W. Chan, O. S. Tang, W. S. B. Yeung, and P. C. Ho Factors affecting endometrial and subendometrial blood flow measured by three-dimensional power Doppler ultrasound during IVF treatment Hum. Reprod., April 1, 2006; 21(4): 1062 - 1069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Y. Ng, C. C. W. Chan, O. S. Tang, W. S. B. Yeung, and P. C. Ho The role of endometrial and subendometrial blood flows measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during IVF treatment Hum. Reprod., January 1, 2006; 21(1): 164 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Simon, J. Oberye, J. Bellver, C. Vidal, E. Bosch, J.A. Horcajadas, C. Murphy, S. Adams, A. Riesewijk, B. Mannaerts, et al. Similar endometrial development in oocyte donors treated with either high- or standard-dose GnRH antagonist compared to treatment with a GnRH agonist or in natural cycles Hum. Reprod., December 1, 2005; 20(12): 3318 - 3327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Soderstrom-Anttila, S. Makinen, T. Tuuri, and A.-M. Suikkari Favourable pregnancy results with insemination of in vitro matured oocytes from unstimulated patients Hum. Reprod., June 1, 2005; 20(6): 1534 - 1540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Yu Ng, C. Chi Wai Chan, O. S. Tang, W. Shu Biu Yeung, and P. C. Ho Endometrial and subendometrial blood flow measured by three-dimensional power Doppler ultrasound in patients with small intramural uterine fibroids during IVF treatment Hum. Reprod., February 1, 2005; 20(2): 501 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N.J. Raine-Fenning, B.K. Campbell, N.R. Kendall, J.S. Clewes, and I.R. Johnson Endometrial and subendometrial perfusion are impaired in women with unexplained subfertility Hum. Reprod., November 1, 2004; 19(11): 2605 - 2614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Y. Ng, C. C. W. Chan, O. S. Tang, W. S. B. Yeung, and P. C. Ho Comparison of endometrial and subendometrial blood flow measured by three-dimensional power Doppler ultrasound between stimulated and natural cycles in the same patients Hum. Reprod., October 1, 2004; 19(10): 2385 - 2390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Y. Ng, C. C. W. Chan, O. S. Tang, W. S. B. Yeung, and P. C. Ho Endometrial and subendometrial blood flow measured during early luteal phase by three-dimensional power Doppler ultrasound in excessive ovarian responders Hum. Reprod., April 1, 2004; 19(4): 924 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N.J. Raine-Fenning, B.K. Campbell, N.R. Kendall, J.S. Clewes, and I.R. Johnson Quantifying the changes in endometrial vascularity throughout the normal menstrual cycle with three-dimensional power Doppler angiography Hum. Reprod., February 1, 2004; 19(2): 330 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Habara, M. Nakatsuka, H. Konishi, K. Asagiri, S. Noguchi, and T. Kudo Elevated blood flow resistance in uterine arteries of women with unexplained recurrent pregnancy loss Hum. Reprod., January 1, 2002; 17(1): 190 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Kelly, P. Sladkevicius, S. Campbell, and G. Nargund Investigation of the infertile couple: a one-stop ultrasound-based approach Hum. Reprod., December 1, 2001; 16(12): 2481 - 2484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Balasch Investigation of the infertile couple: Investigation of the infertile couple in the era of assisted reproductive technology: a time for reappraisal Hum. Reprod., November 1, 2000; 15(11): 2251 - 2257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.H. Check, C. Dietterich, and D. Lurie Non-homogeneous hyperechogenic pattern 3 days after embryo transfer is associated with lower pregnancy rates Hum. Reprod., May 1, 2000; 15(5): 1069 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.L. Schild, S. Holthaus, J. d'Alquen, R. Fimmers, C. Dorn, H. van der Ven, and M. Hansmann Quantitative assessment of subendometrial blood flow by three-dimensional-ultrasound is an important predictive factor of implantation in an in-vitro fertilization programme Hum. Reprod., January 1, 2000; 15(1): 89 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Raga, F. Bonilla-Musoles, E.M. Casan, O. Klein, and F. Bonilla Assessment of endometrial volume by three-dimensional ultrasound prior to embryo transfer: clues to endometrial receptivity Hum. Reprod., November 1, 1999; 14(11): 2851 - 2854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Chwalisz, E. Winterhager, T. Thienel, and R. E. Garfield Synergistic role of nitric oxide and progesterone during the establishment of pregnancy in the rat* Hum. Reprod., February 1, 1999; 14(2): 542 - 552. [Abstract] [Full Text] [PDF]
|
|