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Human Reproduction Update, Vol.3, No.2 pp.137-157, 1997
© European Society of Human Reproduction and Embryology 1997; all rights reserved

Peptide growth factors and preimplantation development

MT Kane0,z, PM Morgan1 and C Coonan1

0 Physiology Department and 1 Biochemistry Department, University College, Galway, Ireland z Corresponding author Email: michael.kane@ucg.ie

Abstract

This paper examines some of the problems and questions that must be considered in relation to research on the role of growth factors in preimplantation embryos. It reviews and summarizes the large body of work on gene expression of growth factor receptors and ligands in preimplantation embryos and in oviduct and uterine tissue. It also reviews the literature on the effects of gene knockout in preimplantation embryos and concludes with a review of work on the effects of growth factors on cultured embryos.

Keywords: development/embryo/embryo culture/gene expression/growth factor


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