Human Reproduction Update, Vol.7, No.4 pp.384-393, 2001
© European Society of Human Reproduction and Embryology 2001; all rights reserved
Cancer in pregnancy: maternal and fetal implications
1 Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel 2 Department of Medicine ‘A’, Sapir Medical Center, Kfar-Saba, Israel 3 Sackler school of medicine, Tel-Aviv University, Tel-Aviv, Israel
To whom correspondence should be addressed at: Boaz Weisz, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel. e-mail: boazmd{at}inter.net.il
Abstract
Cancer is the second leading cause of death in women during their reproductive years, and complicates approximately 0.1% of all pregnancies. When cancer occurs during gestation it poses immense pressure on the pregnant patient, her relatives and her physicians. As cancer is diagnosed during gestation, it raises conflicts between optimal maternal therapy and fetal well-being. In this review, the available data are analysed regarding the impact of pregnancy on the course of the disease, and the effects of the malignant process and its treatment on both the mother and her fetus. Here, attention is focused on the most common malignancies associated with pregnancy; cervical and breast cancer, malignant melanoma and lymphoma. In addition, attention is focused on the available data regarding the impact of cytotoxic and radiation treatments on the mother and fetus.
Key words: breast cancer / cervical carcinoma / lymphoma / malignant melanoma / pregnancy
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