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Human Reproduction Update, Vol.7, No.4 pp.411-418, 2001
© European Society of Human Reproduction and Embryology 2001; all rights reserved

Genetics and infertility II

Affected sib-pair analysis in endometriosis

Stephen Kennedy1, Simon Bennett2 and Daniel E. Weeks3

1 Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK 2 Oxagen Ltd, Oxford, UK 3 Department of Human Genetics, University of Pittsburgh, PA, USA

To whom correspondence should be addressed at: Stephen Kennedy, Nuffield Department of Obstetrics & Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. e-mail: skennedy{at}molbiol.ox.ac.uk

Abstract

This paper (i) reviews the current clinical and molecular genetic data which strongly suggest that endometriosis has a genetic basis; (ii) outlines the general principles of affected-sib pair analysis; and (iii) describes the Oxford Endometriosis Gene (OXEGENE) Study which aims, using a positional cloning approach, to identify susceptibility genes involved in the development of the disease.

Key words: affected sib-pair analysis / endometriosis / genetics / phenotype-genotype / positional cloning


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