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Human Reproduction Update Advance Access published online on January 27, 2005
Human Reproduction Update, doi:10.1093/humupd/dmh060
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Human Reproduction Update © European Society of Human Reproduction and Embryology 2004; all rights reserved

Review

Hydatidiform mole and triploidy: the role of genomic imprinting in placental development

Koen Devriendt 1

1 Center for Human Genetics, Herestraat 49, B-3000 Leuven, Belgium.koenraad.devriendt@uz.kuleuven.ac.be


  Abstract

Genomic imprinting, the differential expression of paternal and maternal alleles, is involved in the regulation of embryonic and fetal growth and development. In this review, we focus on the genetics of a disorder caused by a global defect in genomic imprinting, the hydatidiform mole. The ratio between the maternal and paternal genomes is critical in determining the development of both the embryonic and extraembryonic tissues, with an excess of paternally derived chromosomes leading to a complete (no maternal genome) or partial (lower amount of maternal chromosomes) mole. The recent identification and molecular studies in biparental complete moles may yield more insight into the regulation of imprinting during gametogenesis.

Keywords: genomic imprinting; hydatidiform mole; methylation; pregnancy; triploidy.
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