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Human Reproduction Update Advance Access published online on August 25, 2005
Human Reproduction Update, doi:10.1093/humupd/dmi030
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received June 6, 2005
Revised July 5, 2005
Accepted July 18, 2005

Article

Are endogenous LH levels during ovarian stimulation for IVF using GnRH analogues associated with the probability of ongoing pregnancy? A systematic review

E.M. Kolibianakis 1*, J. Collins 2, B. Tarlatzis 1, E. Papanikolaou 3, and P. Devroey 3

1 Department of Obstetrics and Gynaecology, Unit for Human Reproduction, Aristotle University of Thessaloniki, Thessaloniki, Greece
2 McMaster University, Hamilton, Ontario; Dalhousie University, Halifax, Nova Scotia, Canada
3 Centre for Reproductive Medicine, Dutch-Speaking Brussels Free University, Brussels, Belgium

* To whom correspondence should be addressed.
E.M. Kolibianakis, E-mail: stratis.kolibianakis{at}otenet.gr


  Abstract

The aim of this systematic review was to evaluate, among women with normal ovulation or World Health Organization (WHO) II oligoanovulation who undergo ovarian stimulation for IVF using GnRH analogues, whether endogenous LH levels predict the likelihood of ongoing pregnancy beyond 12 weeks. A literature search identified six studies that answered the research question, among which two were prospective studies (one in GnRH agonist and one in GnRH antagonist cycles). None of the retrospective studies suggest that low endogenous LH levels are associated with a significantly decreased probability of ongoing pregnancy beyond 12 weeks in such patients. In the two prospective studies high endogenous LH levels during down-regulation were associated with a decreased probability of ongoing pregnancy beyond 12 weeks. Until further prospective studies modify the existing evidence summarized here, an adverse effect of low endogenous LH levels on the probability of ongoing pregnancy beyond 12 weeks is not a sensible rationale for LH supplementation during ovarian stimulation for IVF using GnRH analogues.

Keywords: GnRH agonists/GnRH antagonists/luteinizing hormone/ongoing pregnancy rate.
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