Skip Navigation



Human Reproduction Update Advance Access published online on January 30, 2006
Human Reproduction Update, doi:10.1093/humupd/dmk001
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
12/3/275    most recent
dmk001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ehmcke, J.
Right arrow Articles by Schlatt, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ehmcke, J.
Right arrow Articles by Schlatt, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received October 10, 2005
Revised November 17, 2005
Accepted December 20, 2005

Article

Spermatogonial stem cells: questions, models and perspectives

Jens Ehmcke 1, Joachim Wistuba 2, and Stefan Schlatt 1 *

1 Department of Cell Biology and Physiology, Center for Research in Reproductive Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
2 Institute of Reproductive Medicine, University of Münster, Domagkstrasse 11, 48149 Münster, Germany

* To whom correspondence should be addressed.
Stefan Schlatt, E-mail: schlatt{at}pitt.edu


  Abstract

This review looks into the phylogeny of spermatogonial stem cells and describes their basic biological features. We are focusing on species-specific differences of spermatogonial stem cell physiology. We propose revised models for the clonal expansion of spermatogonia and for the potential existence of true stem cells and progenitors in primates but not in rodents. We create a new model for the species-specific arrangements of spermatogenic stages which may depend on the variable clonal expansion patterns. We also provide a brief overview of germ cell transplantation as a powerful tool for basic research and its potential use in a clinical setting.

Keywords: germ cell transplantation/phylogeny/species-specific differences/spermatogonial stem cells.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J AndrolHome page
B. K. Han, J. G. Jung, J. Nam, J. K. Moon, J. N. Kim, S. I. Lee, J. K. Kim, H. Kim, and J. Y. Han
Identification of the Major Proteins Produced by Cultured Germline Stem Cells in Chicken
J Androl, November 1, 2009; 30(6): 690 - 702.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. C. Leal, E. R. Cardoso, R. H. Nobrega, S. R. Batlouni, J. Bogerd, L. R. Franca, and R. W. Schulz
Histological and Stereological Evaluation of Zebrafish (Danio rerio) Spermatogenesis with an Emphasis on Spermatogonial Generations
Biol Reprod, July 1, 2009; 81(1): 177 - 187.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
R. J. Ortiz, C. Lizama, V. A. Codelia, and R. D. Moreno
A molecular evaluation of germ cell death induced by etoposide in pubertal rat testes
Mol. Hum. Reprod., June 1, 2009; 15(6): 363 - 371.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. A. Anderson, A. Weddell, H. A. Spoudeas, C. Douglas, S. M. Shalet, G. Levitt, and W. H. B. Wallace
Do doctors discuss fertility issues before they treat young patients with cancer?
Hum. Reprod., October 1, 2008; 23(10): 2246 - 2251.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
R. P. Amann
The Cycle of the Seminiferous Epithelium in Humans: A Need to Revisit?
J Androl, September 1, 2008; 29(5): 469 - 487.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S.-K. Choi, S.-R. Yoon, P. Calabrese, and N. Arnheim
A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations
PNAS, July 22, 2008; 105(29): 10143 - 10148.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
N. Verhofstad, J. O. Linschooten, J. van Benthem, Y. E. Dubrova, H. van Steeg, F. J. van Schooten, and R. W. L. Godschalk
New methods for assessing male germ line mutations in humans and genetic risks in their offspring
Mutagenesis, July 1, 2008; 23(4): 241 - 247.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
C. E. Gargett
Review Article: Stem Cells in Human Reproduction
Reproductive Sciences, July 1, 2007; 14(5): 405 - 424.
[Abstract] [PDF]

Home page
 ReproductionHome page
J. Ehmcke, B. Joshi, S. D Hergenrother, and S. Schlatt
Aging does not affect spermatogenic recovery after experimentally induced injury in mice
Reproduction, January 1, 2007; 133(1): 75 - 83.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
J. Ehmcke and S. Schlatt
A revised model for spermatogonial expansion in man: lessons from non-human primates.
Reproduction, November 1, 2006; 132(5): 673 - 680.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.