Human Reproduction Update Advance Access published online on June 14, 2006
Human Reproduction Update, doi:10.1093/humupd/dml024
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
* To whom correspondence should be addressed. Reproductive function declines at both extremes of human energy balance. The relationship between obesity and reproductive function is complex and incompletely understood. The literature has established the negative impact of excess energy stores on ovulatory function and investigated the mechanisms whereby this occurs. Furthermore, weight loss in obese anovulatory women increases ovulation and conception. Obesity and anti-obesity therapy effects on the endometrium, implantation and early fetal development have received less attention. The discovery of adipok-ines and enterokines greatly expands the ability to investigate the relationship between obesity, therapies to produce weight loss and reproductive function. In this review, we discuss select adipose and enteric signals. We focus on in vitro, animal and human data that lend biological plausibility to adipokines and enterokines as mediators of obesity and reproduction. Very little published work exists that directly addresses adipocyte and enteric signals in this specific role; therefore, much of this review is on the basis of a synthesis of the literature in three areas: (i) in vitro and in vivo evidence regarding the reproductive effects of these signals; (ii) adipokine and enterokine changes that occur with weight-loss therapies, focusing on hypocaloric diets, bariatric surgery and drugs that target adipocyte or enteric signals and (iii) reproductive changes produced by these weight-loss therapies.
Received March 15, 2006
Accepted May 15, 2006
Article
Obesity and the role of gut and adipose hormones in female reproduction
Gabriella G. Gosman 1 *,
Heather I. Katcher 2,
and
Richard S. Legro 3
2 Department of Nutritional Sciences, Pennsylvania State University, State College, PA, USA
3 Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, PA, USA
Gabriella G. Gosman, E-mail: ggosman{at}mail.magee.edu
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C.H. Ramlau-Hansen, E.A. Nohr, A.M. Thulstrup, J.P. Bonde, L. Storgaard, and J. Olsen Is maternal obesity related to semen quality in the male offspring? A pilot study Hum. Reprod., October 1, 2007; 22(10): 2758 - 2762. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. H. Ramlau-Hansen, A. M. Thulstrup, J. P. Bonde, and J. Olsen Parental Infertility and Semen Quality in Male Offspring: A Follow-up Study Am. J. Epidemiol., September 1, 2007; 166(5): 568 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.H. Ramlau-Hansen, A.M. Thulstrup, E.A. Nohr, J.P. Bonde, T.I.A. Sorensen, and J. Olsen Subfecundity in overweight and obese couples Hum. Reprod., June 1, 2007; 22(6): 1634 - 1637. [Abstract] [Full Text] [PDF]
|
|