Cytoplasmic Ca2+ concentration regulates several key functions in sperm including acrosome reaction and motility. The cover picture depicts a two-store model for Ca2+ signalling in human spermatozoa. Plasma membrane Ca2+ ATPases (PMCA) and Na+–Ca2+ exchangers (NCX) are shown in green; Ca2+ channels in the plasma membrane are shown in red; sarcoplasmic–endoplasmic reticulum ATPases (SERCAs) on intracellular stores are shown in blue and channels for mobilization of stored Ca2+ are shown in orange. Identified or putative components of the Ca2+-signalling toolkit are labelled (using the same colour coding) adjacent to their localization. See pages 253–268.
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