The front cover shows some of the means of activation of transformation related protein 53 (p53). Mitogenic signalling or cell stress (shown in blue boxes) can activate P53 and this can lead to synthesis of apoptotic mediators (e.g. BAX) or cell-cycle inhibitors (e.g. CDKN1A). Survival factor signalling via PI3 kinase (shown in yellow boxes) can mitigate P53 action directly by activating MDM2 or indirectly by blocking BAX by generation of pro-survival mediators such as BCL2 or BCLXL. Interactions leading to activation of a response are shown with black arrows; inhibitory interactions are shown with red bars, (see O'Neill, pp. 275-288).
[Table of Contents]